Recent advances in therapeutical applications of the versatile hydroxypyridinone chelators

IF 2.3 4区 化学 Q2 Agricultural and Biological Sciences
Shailza Sharma, Minati Baral, B. K. Kanungo
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引用次数: 1

Abstract

Hydroxypyridinones (HOPOs) are excellent class of chelators that have been gaining attention in the field of pharmaceutical drugs by their high chelating efficacy and specificity with different metal ions. Among all the metal ions, they exhibit a high binding affinity towards iron (III) and are clinically used as iron chelators nowadays. The HOPO family has different isomers, out of which 3,4-HOPO possesses applicability for designing drugs. The effect of methyl substitution on different positions of pyridinone ring also plays an essential role in deciding the pM values, thus describing the metal affinity. Several metal ions like Fe, Al, Cu, Zn, and some actinides are found to exhibit good chelation efficacy with HOPOs. In terms of denticity, there are various forms of HOPO. Among these, discussion on bidentate, tetradentate, hexadentate, octadentate, and dendrimers will be done here. This review systematically summarizes the various literature reports on the design and pharmacological activities of the newly developed HOPOs and their derivatives, including antibiotics, anticancer, and antineurodegeneratives.

Abstract Image

多用途羟基吡啶酮螯合剂治疗应用的最新进展
羟基吡啶酮(hopo)是一类优秀的螯合剂,因其与不同金属离子的高螯合效能和特异性而受到医药领域的关注。在所有的金属离子中,它们对铁(III)具有较高的结合亲和力,目前在临床上被用作铁螯合剂。HOPO家族有不同的异构体,其中3,4-HOPO具有设计药物的适用性。甲基取代对吡啶酮环不同位置的影响也对决定pM值起重要作用,从而描述金属亲和力。铁、铝、铜、锌等金属离子和一些锕系元素与hopo具有良好的螯合效果。就密度而言,HOPO有多种形式。其中,关于双齿,四齿,六齿,八齿和树状大分子的讨论将在这里进行。本文系统地综述了新开发的hopo及其衍生物的设计和药理活性的各种文献报道,包括抗生素、抗癌和抗神经退行性药物。
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来源期刊
CiteScore
3.30
自引率
8.70%
发文量
0
审稿时长
3-8 weeks
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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