The role of the applied load in bone homeostasis and its implications in implant dentistry: a mini-review

Q4 Medicine

Italian journal of anatomy and embryology Pub Date : 2022-12-27 DOI:10.36253/ijae-13786

F. Valente, O. Trubiani, T. Traini

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Abstract

The aim of this work is to carry out a review about the role of applied load on bone development and homeostasis and its implications in dental implantology. The history of theoretical bone physiology has been evaluated in detail. The modern theory of bone physiology is consistent with the integration among regional acceleratory phenomenon, Utah paradigm, and mechanostat hypothesis: bone modelling and remodelling respond to pleiotropic stimuli. To date, several histologic, in silico and in vitro studies in implant dentistry corroborate the theories about bone physiology. However, each evaluation method has pros and cons, providing analytical data that can only be used to esteem the in vivo behaviour of the bone-implant system. There is the need of further research with highly validated methods and improved measurement devices, to better integrate data form different research types. This would progressively lead to more structured comprehension of the in vivo performance of dental implants and their surrounding bone, and hopefully to a clear definition of the impact of loading on implant failure.

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应用载荷在骨稳态中的作用及其在种植牙科中的意义:一个小型综述

这项工作的目的是对所施加的载荷在骨发育和稳态中的作用及其在牙种植学中的意义进行综述。对理论骨生理学的历史进行了详细的评价。现代骨生理学理论与区域加速现象、犹他范式和机械稳定假说的结合是一致的：骨建模和重塑对多效性刺激做出反应。到目前为止，种植牙的一些组织学、计算机和体外研究证实了骨生理学的理论。然而，每种评估方法都有优缺点，提供的分析数据只能用于评估骨植入系统的体内行为。需要用高度验证的方法和改进的测量设备进行进一步的研究，以更好地整合不同研究类型的数据。这将逐步导致对牙科植入物及其周围骨骼的体内性能的更结构化的理解，并有望对载荷对植入物失效的影响有一个明确的定义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Italian journal of anatomy and embryology Medicine-Embryology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： The Italian Journal of Anatomy and Embryology, founded in 1901 by Giulio Chiarugi, Anatomist at Florence University, is a peer-reviewed journal sponsored by the Italian Society of Anatomy and Embryology. The journal publishes original papers, invited review articles, historical article, commentaries, obituitary, and book reviews. Its main focus is to understand anatomy through an analysis of structure, function, development and evolution. Priority will be given to studies of that clearly articulate their relevance to the anatomical community. Focal areas include: experimental studies, contributions based on molecular and cell biology and on the application of modern imaging techniques; comparative functional morphology; developmental biology; functional human anatomy; methodological innovations in anatomical research; significant advances in anatomical education. Studies that are essentially descriptive anatomy are appropriate only if they communicate clearly a broader functional or evolutionary significance. All papers should be submitted in English and must be original works that are unpublished and not under consideration by another journal. An international Editorial Board and reviewers from the anatomical disciplines guarantee a rapid review of your paper within two to three weeks after submission.