The efficacy of combined micronized Niclosamideand Albendazole-based dosage forms against bothriocephalosis of cyprinids

Abstract

The purpose of the research is to develop and test new combined dosage forms against bothriocephalosis of cyprinids in the cage culture fishery.Materials and methods. Combined micronized Niclosamide- and Albendazole-based dosage forms were developed; labscale batches of dosage forms of drugs and medicated feeds were developed with these drug forms; Bothriocephalus sp. infection rate in fish was determined during the growing period; and preliminary test effectiveness was confirmed for combined micronized niclosamide- and albendazole-based dosage forms against bothriocephalosis in cyprinids in the incubation shop of a cage culture fishery according to standard practices. The efficacy was assessed for combined micronized niclosamide- and albendazole-based dosage forms.Results and discussion. The preliminary tests of combined micronized Albendazole- and Niclosamide-based dosage forms as part of medicated feeds showed 100% extense-effectiveness with 100% intense-effectiveness, and 60% extenseeffectiveness with 77.8% intense-effectiveness when administered once at a dose of 5% of the fish weight (doses for the active substance of 50 and 40 mg/kg, respectively).