{"title":"Potential Synthetic Routes and Metal-Ion Sensing Applications of 1,3,4-Oxadiazoles: An Integrative Review.","authors":"Deepak Sharma, Hari Om, Ashok Kumar Sharma","doi":"10.1080/10408347.2022.2080494","DOIUrl":null,"url":null,"abstract":"<p><p>Oxadiazoles, especially 1,3,4-oxadiazole scaffolds, stand among the foremost heterocyclic fragments with a broad spectrum of applications in diverse fields, including pharmacology, polymers, material science, and organic electronics, among others. In this comprehensive review, we summarize the pivotal synthetic strategies for 1,3,4-oxadiazole derivatives including dehydrogenative cyclization of 1,2-diacylhydrazines, oxidative cyclization of acylhydrazones, condensation cyclization, C-H activation of oxadiazole ring, decarboxylative cyclization and oxidative annulation along with plausible mechanisms. The set of 1,3,4-oxadiazoles selected from the literature and discussed herein epitomize the ease of synthesis as well as the possibility of linking π-conjugated groups; thereby encouraging the use of these molecules as important starting building blocks for a wide variety of fluorescent frameworks, particularly in the development of potential chemosensors. High photoluminescent quantum yield, excellent thermal and chemical stability, and the presence of potential coordination (N and O donor atoms) sites make these molecules a prominent choice for metal-ions sensors. An overview of selective metal-ion sensing, the detection limit along with the sensing mechanisms (photo-induced electron transfer, excited-state intramolecular proton transfer, and complex formation) is also included.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":null,"pages":null},"PeriodicalIF":4.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in analytical chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/10408347.2022.2080494","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/26 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Oxadiazoles, especially 1,3,4-oxadiazole scaffolds, stand among the foremost heterocyclic fragments with a broad spectrum of applications in diverse fields, including pharmacology, polymers, material science, and organic electronics, among others. In this comprehensive review, we summarize the pivotal synthetic strategies for 1,3,4-oxadiazole derivatives including dehydrogenative cyclization of 1,2-diacylhydrazines, oxidative cyclization of acylhydrazones, condensation cyclization, C-H activation of oxadiazole ring, decarboxylative cyclization and oxidative annulation along with plausible mechanisms. The set of 1,3,4-oxadiazoles selected from the literature and discussed herein epitomize the ease of synthesis as well as the possibility of linking π-conjugated groups; thereby encouraging the use of these molecules as important starting building blocks for a wide variety of fluorescent frameworks, particularly in the development of potential chemosensors. High photoluminescent quantum yield, excellent thermal and chemical stability, and the presence of potential coordination (N and O donor atoms) sites make these molecules a prominent choice for metal-ions sensors. An overview of selective metal-ion sensing, the detection limit along with the sensing mechanisms (photo-induced electron transfer, excited-state intramolecular proton transfer, and complex formation) is also included.
期刊介绍:
Critical Reviews in Analytical Chemistry continues to be a dependable resource for both the expert and the student by providing in-depth, scholarly, insightful reviews of important topics within the discipline of analytical chemistry and related measurement sciences. The journal exclusively publishes review articles that illuminate the underlying science, that evaluate the field''s status by putting recent developments into proper perspective and context, and that speculate on possible future developments. A limited number of articles are of a "tutorial" format written by experts for scientists seeking introduction or clarification in a new area.
This journal serves as a forum for linking various underlying components in broad and interdisciplinary means, while maintaining balance between applied and fundamental research. Topics we are interested in receiving reviews on are the following:
· chemical analysis;
· instrumentation;
· chemometrics;
· analytical biochemistry;
· medicinal analysis;
· forensics;
· environmental sciences;
· applied physics;
· and material science.