Consanguinity and Positive Family History of Inflammatory Bowel Diseases in Children: A Multicenter Case–Control Study

IF 0.3 Q4 PEDIATRICS

Journal of Child Science Pub Date : 2022-09-29 DOI:10.1055/s-0042-1757148

M. Hasosah

{"title":"Consanguinity and Positive Family History of Inflammatory Bowel Diseases in Children: A Multicenter Case–Control Study","authors":"M. Hasosah","doi":"10.1055/s-0042-1757148","DOIUrl":null,"url":null,"abstract":"Inflammatory bowel diseases (IBD), which comprise Crohn's disease (CD) and ulcerative colitis (UC), are rising trend in Saudi population. We aim to examine the association between consanguinity and family history and the risk of childhood IBD in Saudi children. A multicenter case–control study conducted in three tertiary hospitals in Jeddah and Riyadh, Saudi Arabia, during periods 2009 to 2021. Data about demographics, consanguinity, family history of IBD, and type of IBD were collected using a structured questionnaire. The same questionnaire was applied in matched case–control. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression analysis that was performed to compare both groups. The study population included 335 children: 167 IBD patients (49.9%) and 168 controls (50.1%). Of these IBD, 93 patients (56%) were CD and 74 patients (44%) were UC. Most of participants were females (72.1%) and their age more than 10 years (51.5%). There was first-degree consanguinity in 66 IBD patients (49.6%). No significant difference in first-degree consanguinity between cases and controls was noted (49.6% in cases vs. 50.4% in controls; OR = 1.02; 95% CI = 0.66–1.57). The consanguinity showed a more significant association with CD than UC (p < 0.05). Family history of IBD (father, siblings, and grandparents) as risk factors for IBD was identified: paternal history of IBD (OR = 0.25, 95% CI = 0.08–0.76), siblings' history of IBD (OR = 2.16, 95% CI = 1.92–2.43), and grandparent's history of IBD (OR = 0.22, 95% CI = 0.07–0.65). Family history of IBD showed a more significant association with CD than UC (p < 0.05). Consanguinity is strongly associated with IBD with more significant association with CD than UC and may possibly explain IBD rise in Saudi Arabia. The greatest risk of family history of IBD is in first-degree relatives, especially in siblings' rather than parents and grandparents.","PeriodicalId":41283,"journal":{"name":"Journal of Child Science","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Child Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/s-0042-1757148","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Inflammatory bowel diseases (IBD), which comprise Crohn's disease (CD) and ulcerative colitis (UC), are rising trend in Saudi population. We aim to examine the association between consanguinity and family history and the risk of childhood IBD in Saudi children. A multicenter case–control study conducted in three tertiary hospitals in Jeddah and Riyadh, Saudi Arabia, during periods 2009 to 2021. Data about demographics, consanguinity, family history of IBD, and type of IBD were collected using a structured questionnaire. The same questionnaire was applied in matched case–control. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression analysis that was performed to compare both groups. The study population included 335 children: 167 IBD patients (49.9%) and 168 controls (50.1%). Of these IBD, 93 patients (56%) were CD and 74 patients (44%) were UC. Most of participants were females (72.1%) and their age more than 10 years (51.5%). There was first-degree consanguinity in 66 IBD patients (49.6%). No significant difference in first-degree consanguinity between cases and controls was noted (49.6% in cases vs. 50.4% in controls; OR = 1.02; 95% CI = 0.66–1.57). The consanguinity showed a more significant association with CD than UC (p < 0.05). Family history of IBD (father, siblings, and grandparents) as risk factors for IBD was identified: paternal history of IBD (OR = 0.25, 95% CI = 0.08–0.76), siblings' history of IBD (OR = 2.16, 95% CI = 1.92–2.43), and grandparent's history of IBD (OR = 0.22, 95% CI = 0.07–0.65). Family history of IBD showed a more significant association with CD than UC (p < 0.05). Consanguinity is strongly associated with IBD with more significant association with CD than UC and may possibly explain IBD rise in Saudi Arabia. The greatest risk of family history of IBD is in first-degree relatives, especially in siblings' rather than parents and grandparents.

查看原文本刊更多论文

儿童炎症性肠病的血缘和阳性家族史：一项多中心病例对照研究

炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），在沙特人口中呈上升趋势。我们的目的是研究沙特儿童的血缘关系和家族史与儿童IBD风险之间的关系。2009年至2021年期间，在沙特阿拉伯吉达和利雅得的三家三级医院进行的一项多中心病例对照研究。使用结构化问卷收集有关人口统计学、血缘关系、IBD家族史和IBD类型的数据。在匹配的病例对照中采用了相同的问卷调查。比值比（OR）和95%置信区间（CI）使用无条件逻辑回归分析进行估计，该分析用于比较两组。研究人群包括335名儿童：167名IBD患者（49.9%）和168名对照组（50.1%）。在这些IBD中，93名患者（56%）为CD，74名患者（44%）为UC。大多数参与者是女性（72.1%），年龄超过10岁（51.5%）。66名IBD患者（49.6%）有一级血缘关系。病例和对照组之间的一级血缘没有显著差异（病例为49.6%，对照组为50.4%；OR = 1.02；95%CI = 0.66–1.57）。与UC相比，血缘关系与CD的相关性更为显著（p < 0.05）。IBD家族史（父亲、兄弟姐妹和祖父母）是IBD的危险因素：父亲有IBD病史（OR = 0.25，95%CI = 0.08–0.76），兄弟姐妹有IBD病史（OR = 2.16，95%CI = 1.92–2.43），以及祖父母的IBD病史（OR = 0.22，95%CI = 0.07–0.65）。IBD家族史与CD的相关性高于UC（p < 0.05）。血缘关系与IBD密切相关，与CD的相关性比UC更显著，这可能解释了沙特阿拉伯IBD的增加。IBD家族史风险最大的是一级亲属，尤其是兄弟姐妹，而不是父母和祖父母。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Child Science PEDIATRICS-

CiteScore

0.50

自引率

0.00%

发文量