The ergogenic effect of acute carnosine and anserine supplementation: dosing, timing, and underlying mechanism

IF 4.5 2区 医学 Q1 NUTRITION & DIETETICS
S. de Jager, L. Blancquaert, Thibaux Van der Stede, E. Lievens, S. De Baere, S. Croubels, E. Gilardoni, L. Regazzoni, G. Aldini, J. Bourgois, W. Derave
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引用次数: 6

Abstract

ABSTRACT Background Recent studies suggest that acute-combined carnosine and anserine supplementation has the potential to improve the performance of certain cycling protocols. Yet, data on optimal dose, timing of ingestion, effective exercise range, and mode of action are lacking. Three studies were conducted to establish dosing and timing guidelines concerning carnosine and anserine intake and to unravel the mechanism underlying the ergogenic effects. Methods First, a dose response study A was conducted in which 11 men randomly received placebo, 10, 20, or 30 mg.kg−1 of both carnosine and anserine. They performed 3x maximal voluntary isometric contractions (MVC), followed by a 5 x 6 s repeated cycling sprint ability test (RSA), once before the supplement and 30 and 60 minutes after. In a second study, 15 men performed 3x MVCs with femoral nerve electrical stimulation, followed by an RSA test, once before 30 mg.kg−1 carnosine and anserine and 60 minutes after. Finally, in study C, eight men performed a high intensity cycling training after randomly ingesting 30 mg.kg−1 of carnosine and anserine, a placebo or antihistamines (reduce post-exercise blood flow) to investigate effects on muscle perfusion. Results Study A showed a 3% peak power (p = 0.0005; 95% CI = 0.07 to 0.27; ES = 0.91) and 4.5% peak torque (p = 0.0006; 95% CI = 0.12 to 0.50; ES = 0.87) improvement on RSA and MVC, with 30 mg.kg−1 carnosine + anserine ingestion 60 minutes before the performance yielding the best results. Study B found no performance improvement on group level; however, a negative correlation (r = −0.54; p = 0.0053; 95% CI = −0.77 to −0.19) was found between carnosinase enzyme activity (responsible for carnosine and anserine breakdown) and performance improvement. No effect of the supplement on neuromuscular function nor on muscle perfusion was found. Conclusions These studies reveal that acute ingestion of 30 mg.kg−1 of both carnosine and anserine, 60 minutes before a high intensity exercise, can potentially improve performance, such as short cycling sprints or maximal muscle contractions. Subjects with lower carnosinase activity, and thus a slower breakdown of circulating dipeptides, appear to benefit more from this ergogenic effect. Finally, neither the involvement of a direct effect on neuromuscular function, nor an indirect effect on recovery through increased muscle perfusion could be confirmed as potential mechanism of action. The ergogenic mechanism therefore remains elusive.
急性补充肌肽和丝氨酸的麦角效应:给药、时间和潜在机制
摘要背景最近的研究表明,急性联合补充肌肽和丝氨酸有可能改善某些循环方案的性能。然而,缺乏关于最佳剂量、摄入时间、有效运动范围和行动模式的数据。进行了三项研究,以确定肌肽和丝氨酸摄入的剂量和时间指南,并揭示麦角效应的潜在机制。方法首先,进行一项剂量反应研究a,其中11名男性随机接受安慰剂、10、20或30 mg/kg−1的肌肽和丝氨酸。他们进行了3次最大自主等长收缩(MVC),然后进行了5 x 6 s的重复循环冲刺能力测试(RSA),在补充前一次,补充后30和60分钟。在第二项研究中,15名男性用股神经电刺激进行了3次MVC,然后进行RSA测试,在30 mg/kg−1肌肽和丝氨酸之前进行一次,在60分钟之后进行一次。最后,在研究C中,八名男性在随机摄入30毫克/公斤-1的肌肽和丝氨酸、安慰剂或抗组胺药(减少运动后血流量)后进行了高强度自行车训练,以研究对肌肉灌注的影响。结果研究A显示,RSA和MVC的峰值功率(p=0.0005;95%CI=0.07至0.27;ES=0.91)提高了3%,峰值扭矩(p=.0006;95%CI=0.12至0.50;ES=0.87)提高了4.5%,在表现前60分钟摄入30 mg/kg−1肌肽+丝氨酸产生最佳结果。研究B发现,在小组水平上没有表现改善;然而,在肌肽酶活性(负责肌肽和丝氨酸的分解)和性能提高之间发现了负相关(r=−0.54;p=0.0053;95%CI=−0.77至−0.19)。未发现该补充剂对神经肌肉功能和肌肉灌注的影响。结论这些研究表明,在高强度运动前60分钟,急性摄入30 mg·kg−1的肌肽和丝氨酸,可能会提高表现,如短时间的自行车短跑或最大限度的肌肉收缩。肌肽酶活性较低,因此循环二肽分解较慢的受试者似乎从这种麦角效应中受益更多。最后,无论是对神经肌肉功能的直接影响,还是通过增加肌肉灌注对恢复的间接影响,都不能被证实是潜在的作用机制。因此,人体工程学机制仍然难以捉摸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the International Society of Sports Nutrition
Journal of the International Society of Sports Nutrition NUTRITION & DIETETICS-SPORT SCIENCES
CiteScore
8.80
自引率
3.90%
发文量
34
审稿时长
6-12 weeks
期刊介绍: Journal of the International Society of Sports Nutrition (JISSN) focuses on the acute and chronic effects of sports nutrition and supplementation strategies on body composition, physical performance and metabolism. JISSN is aimed at researchers and sport enthusiasts focused on delivering knowledge on exercise and nutrition on health, disease, rehabilitation, training, and performance. The journal provides a platform on which readers can determine nutritional strategies that may enhance exercise and/or training adaptations leading to improved health and performance.
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