Stellaria media attenuates the hyperglycemia and hyperlipidemia in alloxan-induced diabetic rat

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2019-04-28 DOI:10.3329/bjp.v14i2.39847

R. Khan, W. Ahmad, Mushtaq Ahmed

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引用次数: 4

Abstract

Abstract The objective of this research work was to assess the hyperglycemic and hyperlipidemiceffects of Stellaria media in alloxan induced diabetic rats using different experimental models. Standard documented protocols were used to concede the in vitro and in vivo activities. Biochemical markers studies were also done. The results of the study showed strong pancreatic α-amylase and β-glucosidase inhibition in-vitroat varying concentrations of the extract which further validated the in-vivo anti-diabetic action of the plant because of the inhibition of the above enzymes.The administration of various concentrations of the extract showedmomentous decrease in fasting blood level when compared to diabetic control. Similarly, remarkably improved hemoglobin (+20.10%), and decreased HbA1c (−48.44%) was observed when compared to diabetic control rats. The extract also caused reduced serum enzyme (ALT, ALP, bilirubin) levels and produced a succeeding recovery toward their normal values.It can be concluded from these investigations that the in-vitro and in-vivo hypoglycemic and hypolipidemic activity offers the methodicaljustification for the use of S. media in herb based anti-diabetic treatment.

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星状介质对四氧嘧啶诱导的糖尿病大鼠高血糖和高脂血症的影响

摘要本研究的目的是使用不同的实验模型来评估Stellaria培养基对四氧嘧啶诱导的糖尿病大鼠的高血糖和高脂血症的影响。使用标准记录的方案来承认体外和体内活性。还进行了生化标记研究。研究结果显示，在不同浓度的提取物中，胰腺α-淀粉酶和β-葡萄糖苷酶具有强烈的抑制作用，这进一步验证了由于上述酶的抑制，植物的体内抗糖尿病作用。与糖尿病对照组相比，给予不同浓度的提取物显示空腹血液水平显著下降。同样，与糖尿病对照大鼠相比，观察到血红蛋白显著改善（+20.10%），HbA1c降低（-48.44%）。提取物还导致血清酶（ALT、ALP、胆红素）水平降低，并使其逐渐恢复到正常值。从这些研究中可以得出结论，体外和体内的降血糖和降血脂活性为S.media用于草药抗糖尿病治疗提供了系统的理由。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.