Rheumatoid pain models in rodents and the application of dynamic weight-bearing test

Dawei Geng, Liming Wang, N. Liu, Jian Qin
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Abstract

Rheumatoid arthritis (RA) is an autoimmune systemic disease of unknown etiology, characterized by chronic inflammation and synovial infiltration of immune cells. Pain is one of the most dominant symptoms for patients with RA, which affects the health and quality of life. Animal models are helpful to study the pathogenesis of RA and related factors and mechanisms of RA-induced pain, which may aid in the development of new and better treatment strategies. Several animal models of RA have been validated to predict for efficacy in humans that include collagen type II-induced arthritis in rats and mice, adjuvant-induced arthritis in rats, and antigen induced arthritis in several species. However, the quantitative evaluation of pain in animal models is technically challenging. Until recent years, behavior methods are used to characterize acute and chronic pain stages by observing behavioral changes in preclinical arthritis models. Significant progress has been made in pain assessment with the development of nonreflexive tools, dynamic weight-bearing (DWB) apparatus was developed for the measurement of pain in rodents by capturing weight-bearing and surface distribution of the paws. In this article, we summarize several classical animal models of rheumatoid pain as well as discussion of the advantages and disadvantages of DWB test for spontaneous pain used in these models.
啮齿类动物类风湿性疼痛模型及动态负重试验的应用
类风湿性关节炎(RA)是一种病因不明的自身免疫性系统性疾病,以慢性炎症和免疫细胞滑膜浸润为特征。疼痛是RA患者最主要的症状之一,影响健康和生活质量。动物模型有助于研究RA的发病机制以及RA引起疼痛的相关因素和机制,有助于开发新的更好的治疗策略。RA的几种动物模型已被验证可预测对人类的疗效,包括大鼠和小鼠中II型胶原诱导的关节炎、大鼠中佐剂诱导的关节痛和几种物种中抗原诱导的关节病。然而,在动物模型中对疼痛进行定量评估在技术上具有挑战性。直到最近几年,行为方法还被用来通过观察临床前关节炎模型中的行为变化来表征急性和慢性疼痛阶段。随着非弹性工具的开发,疼痛评估取得了重大进展,开发了动态负重(DWB)装置,通过捕捉爪子的负重和表面分布来测量啮齿动物的疼痛。在这篇文章中,我们总结了几种典型的类风湿性疼痛动物模型,并讨论了DWB试验在这些模型中用于自发性疼痛的优缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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