Clinical study on the effect of hyperbaric oxygen assisted therapy on neuroprotein level in children with viral encephalitis

国际医药卫生导报 Pub Date : 2019-04-15 DOI:10.3760/CMA.J.ISSN.1007-1245.2019.08.005

Li Qianqian

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Abstract

Objective To investigate the effect of hyperbaric oxygen (HBO) on the levels of neuro-related proteins in children with viral encephalitis. Methods 74 cases of children with viral encephalitis in our hospital from March 2017 to October 2018 were divided into control group (n=37) and experimental group (n=37) according to different treatment methods. The control group was given routine treatment, and the experimental group was given hyperbaric oxygen treatment on the basis of the above. The clinical efficacy, changes of serum neuron specific enolase (NSE), beta-endorphin (beta-EP), myelin basic protein (MBP) before and after treatment, and recovery time of vital signs were observed. Results Before treatment, there were no statistically significant differences in the levels of neuro-related proteins between the two groups (P>0.05); after treatment, the contents of NSE, beta-EP, and MBP in the experimental group significantly decreased, and the total cure rate of the experimental group was significantly higher (91.89% vs.62.16%), the recovery time of vital signs significantly shortened, with statistically significant differences compared with the control group (P<0.05). Conclusion Hyperbaric oxygen therapy can not only effectively reduce the levels of neuro-related proteins in children with viral encephalitis, improve the total clinical cure rate and shorten the recovery time of vital signs. Key words: Hyperbaric oxygen; Children; Viral encephalitis; Neuroprotein level

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高压氧辅助治疗对病毒性脑炎患儿神经蛋白水平影响的临床研究

目的探讨高压氧对病毒性脑炎患儿神经相关蛋白水平的影响。方法将我院2017年3月至2018年10月收治的74例病毒性脑炎患儿按不同治疗方法分为对照组（n=37）和实验组（n=27）。对照组给予常规治疗，实验组在此基础上给予高压氧治疗。观察临床疗效、治疗前后血清神经元特异性烯醇化酶（NSE）、β-内啡肽（β-EP）、髓鞘碱性蛋白（MBP）的变化以及生命体征的恢复时间。结果治疗前两组神经相关蛋白水平差异无统计学意义（P>0.05）；治疗后，实验组NSE、β-EP和MBP含量显著下降，总治愈率显著高于对照组（91.89%比62.16%），生命体征恢复时间显著缩短，结论高压氧治疗不仅能有效降低病毒性脑炎患儿神经相关蛋白水平，提高临床总治愈率，缩短生命体征恢复时间。关键词：高压氧；儿童；病毒性脑炎；神经蛋白水平

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国际医药卫生导报

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