Annotated Review on Various Biological Activities of Quinoline Molecule

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-17 DOI:10.33263/briac134.355

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引用次数: 1

Abstract

Quinoline or Benzopyridine moiety remained an attraction among researchers in the 21st century. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. This moiety is considered a biologically important active source that possesses all types of medicinal potentials due to its simple chemistry, ease of synthesis, and a wide variety of numerous biological potentials in both natural and synthetic derivatives such as antimalarial, antibacterial, anti-inflammatory, anti-arrhythmic, anti-anginal, antihypertensive, anti-depressant, anti-convulsant. This pharmacological diversity of quinoline has attracted researchers to explore this moiety by making modifications at various possible positions. In the present review, we are outlining the potential of quinoline as an antimalarial, anticancer, anti-inflammatory, and antibacterial agent. Furthermore, by attaining the knowledge of molecular targets, structural insights, and SARs, this review may be supportive for medicinal chemists to design more potent, safe, selective, and cost-effective quinoline derivatives for various biological properties.

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喹啉分子的多种生物活性评述

喹啉或苯并吡啶部分在21世纪仍然吸引着研究人员。喹啉是一种杂环芳香族有机化合物，化学式为C9H7N。该部分被认为是一种重要的生物活性来源，由于其化学简单、易于合成，以及在天然和合成衍生物中具有多种多样的生物潜力，如抗疟、抗菌、抗炎、抗心律失常、抗心绞痛、抗高血压、抗抑郁、抗惊厥剂，因此具有所有类型的药用潜力。喹啉的这种药理学多样性吸引了研究人员通过在各种可能的位置进行修饰来探索这一部分。在本综述中，我们概述了喹啉作为抗疟、抗癌、抗炎和抗菌剂的潜力。此外，通过获得分子靶标、结构见解和严重急性呼吸系统综合征的知识，这篇综述可能有助于药物化学家为各种生物特性设计更有效、安全、选择性和成本效益更高的喹啉衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.