“The Good, the Bad and the Ugly”: Interplay of Innate Immunity and Inflammation

IF 2.6 2区 生物学 Q3 CELL BIOLOGY
M. Alemán
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引用次数: 0

Abstract

Innate immunity recognizes microorganisms through certain invariant receptors named pattern recognition receptors (PRRs) by sensing conserved pathogen-associated molecular patterns (PAMPs). Their recognition activates several signaling pathways that lead the transcription of inflammatory mediators, contributing to trigger a very rapid inflammatory cascade aiming to contain the local infection as well as activating and instructing the adaptive immunity in a specific and synchronized immune response according to the microorganism. Inflammation is a coordinated process involving the secretion of cytokines and chemokines by macrophages and neutrophils leading to the migration of other leukocytes along the endothelium into the injured tissue. Sustained inflammatory responses can cause deleterious effects by promoting the development of autoimmune disorders, allergies, cancer, and other immune pathologies, while weak signals could exacerbate the severity of the disease. Therefore, PRR-mediated signal transduction must be tightly regulated to maintain host immune homeostasis. Innate immunity deficiencies and strategies deployed by microbes to avoid inflammatory responses lead to an altered immune response that allows the pathogen to proliferate causing death or uncontrolled inflammation. This review analyzes the complexity of the immune response at the beginning of the disease focusing on COVID-19 disease and the importance of unraveling its mechanisms to be considered when treating diseases and designing vaccines.
“好,坏,丑”:先天免疫和炎症的相互作用
先天免疫通过某些称为模式识别受体(PRRs)的不变受体,通过感知保守的病原体相关分子模式(PAMP)来识别微生物。它们的识别激活了几种引导炎症介质转录的信号通路,有助于触发一种非常快速的炎症级联反应,旨在遏制局部感染,并根据微生物以特定和同步的免疫反应激活和指导适应性免疫。炎症是一个协调的过程,涉及巨噬细胞和中性粒细胞分泌细胞因子和趋化因子,导致其他白细胞沿着内皮迁移到损伤组织中。持续的炎症反应可通过促进自身免疫性疾病、过敏、癌症和其他免疫病理的发展而造成有害影响,而微弱的信号可能会加剧疾病的严重性。因此,必须严格调控PRR介导的信号转导以维持宿主免疫稳态。先天免疫缺陷和微生物为避免炎症反应而采取的策略会导致免疫反应的改变,从而使病原体增殖,导致死亡或不受控制的炎症。这篇综述分析了疾病开始时免疫反应的复杂性,重点是新冠肺炎疾病,以及在治疗疾病和设计疫苗时需要考虑的解开其机制的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cellular Microbiology
Cellular Microbiology 生物-微生物学
CiteScore
9.70
自引率
0.00%
发文量
26
审稿时长
3 months
期刊介绍: Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.
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