Antibacterial Application of Carpathian Clinoptilolite as Cetylpyridinium Carrier

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-09-17 DOI:10.33263/briac134.348

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引用次数: 1

Abstract

A bactericidal and structural study on the "cetylpyridinium chloride-clinoptilolite" associates has been carried out. For the first time, the samples were synthesized using the powdered clinoptilolite from the Sokyrnytsia deposit (Transcarpathian region, Ukraine). Eight "cetylpyridinium chloride-clinoptilolite" associates have been synthesized using different cetylpyridinium chloride concentrations and further characterized by elemental analysis and FTIR techniques. The association of the cetylpyridinium cation with the zeolite anionic matrix has been studied. It was found that the adsorption of the cetylpyridinium cations occurs on the clinoptilolite surface without destroying the anionic zeolite framework. Furthermore, the antibacterial activity of the associates was analyzed, and a significant activity against Staphylococcus aureus and Candida albicans strains was observed, which is caused by the cetylpyridinium cation presence. Unmodified natural and acid-treated clinoptilolites did not show antibacterial activity; however, these can be effectively used as a matrix carrier for the cetylpyridinium cation.

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喀尔巴阡斜发沸石作为十六烷基吡啶载体的抗菌应用

对“十六烷基氯化吡啶斜发沸石”缔合物进行了杀菌和结构研究。首次使用Sokyrnytsia矿床（乌克兰外喀尔巴阡山地区）的粉状斜发沸石合成样品。采用不同浓度的氯化十六烷基吡啶合成了八种“氯化十六烷基哒鎓斜发沸石”缔合物，并通过元素分析和FTIR技术对其进行了表征。研究了十六烷基吡啶鎓阳离子和沸石阴离子基体的缔合作用。研究发现，十六烷基吡啶阳离子在斜发沸石表面发生吸附，而不会破坏阴离子沸石骨架。此外，分析了缔合物的抗菌活性，并观察到对金黄色葡萄球菌和白色念珠菌菌株的显著活性，这是由十六烷基吡啶阳离子的存在引起的。未改性的天然和酸处理的斜发沸石没有显示出抗菌活性；然而，它们可以有效地用作十六烷基吡啶鎓阳离子的基质载体。

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.