Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer

IF 3.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2023-09-01 DOI:10.1007/s11468-023-02022-5

Vikash Kumar, Sanjeev Kumar Raghuwanshi, Santosh Kumar

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引用次数: 0

Abstract

Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO₃, and 2D layering of materials (MoSe₂/WS₂) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS₂ (each of 0.5 nm) and two layers of BaTiO₃ (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU⁻¹), 0.576 (degree⁻¹), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU⁻¹), 0.829 (degree⁻¹), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.

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基于纳米材料的表面等离子体共振传感芯片检测皮肤和乳腺癌症

现代生活中的科技进步大大提高了表面等离子体共振（SPR）传感器的重要性。为了提高传感器的性能，专家们目前正致力于开发一种将棱镜与薄纳米复合层融为一体的 SPR 生物医学传感器。拟议的 SPR 生物传感器采用银、BaTiO3 和二维分层材料（MoSe2/WS2）制成，用于识别皮肤癌和乳腺癌细胞。本分析采用 SPR 的衰减全反射 (ATR) 技术检测皮肤癌（基底细胞）和乳腺癌细胞（MM-231 和 MCF-7），以评估结果。据观察，通过使用厚度分别为 50 纳米和 10 纳米的两种金属银涂层，该装置的有效性得到了提高。通过使用两层 WS2（每层 0.5 纳米）和两层 BaTiO3（每层 5 纳米），可以提高设备的有效性；在皮肤癌的情况下，可以达到最高的灵敏度。数值结果显示，基底细胞的最高灵敏度为 253.5 (°/RIU)，乳腺癌细胞（MM-231 和 MCF-7）的最高灵敏度分别为 309.2857°/RIU和 295.71°/RIU。基底细胞的优度（FoM）、检测精度（DA）和信噪比（SNR）分别为 146.11（RIU-1）、0.576（度-1）和 2.922，乳腺癌的优度（FoM）、检测精度（DA）和信噪比（SNR）分别为 255.66（RIU-1）、0.829（度-1）和 3.59。最后，与之前的研究相比，本手稿得出的数值结果显示了高度的灵敏度和 FoM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.