Genetic Polymorphisms and Generalized Anxiety Disorder: a systematic review

Medical Express Pub Date : 2017-02-01 DOI:10.5935/MEDICALEXPRESS.2017.01.01

V. Alves, Edilson Leite de Moura, L. Correia, A. Nardi

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引用次数: 2

Abstract

OBJECTIVE: Generalized Anxiety Disorder is a disease characterized by feelings of anxiety, fear, excessive worrying and tension in the face of life experiences. This study aims to identify genetic polymorphisms associated with Generalized Anxiety Disorder described in scientific literature. METHOD: This review was set up by searching PubMed/Medline, Web of Science and Scopus database using the following key words: "gene and generalized anxiety disorder", "SNP and generalized anxiety disorder" and "polymorphism and generalized anxiety disorder". RESULTS: We found ten polymorphic varieties of nine genes that showed association and seven polymorphic varieties of three genes that showed no association with Generalized Anxiety disorder: genes NPY, BDNF, BLC2, DED2, RGS2, HTR1A, MAOA, ERS2 and 5-HTT showed association, whereas BDNF, ERS1 and TPH showed no association with the Disorder. Conflicting results regarding BDNF come from different studies. CONCLUSION: This review identified a variety of genetic polymorphisms, that have been studied in relation to Generalized Anxiety Disorder. Taken jointly, their results are inconclusive, showing that more genetic studies focused on this mental disorder are necessary.

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遗传多态性与广泛性焦虑障碍:系统综述

目的:广泛性焦虑障碍是一种以面对生活经历时感到焦虑、恐惧、过度担忧和紧张为特征的疾病。本研究旨在确定科学文献中描述的与广泛性焦虑障碍相关的遗传多态性。方法:检索PubMed/Medline、Web of Science和Scopus数据库，检索关键词为“基因与广泛性焦虑障碍”、“SNP与广泛性焦虑障碍”、“多态性与广泛性焦虑障碍”。结果:发现与广泛性焦虑障碍相关的基因NPY、BDNF、BLC2、DED2、RGS2、HTR1A、MAOA、ERS2、5-HTT等9个基因有10个多态性，与广泛性焦虑障碍无关联的基因有7个多态性，而BDNF、ERS1、TPH与广泛性焦虑障碍无关联。关于BDNF的矛盾结果来自不同的研究。结论:本综述确定了与广泛性焦虑障碍相关的多种遗传多态性。综合来看，他们的结果是不确定的，表明有必要对这种精神障碍进行更多的基因研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medical Express

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审稿时长

12 weeks