No significant association between SNPs in the CLOCK and ADH4 genes and susceptibility to cluster headaches: A systematic review and meta-analysis

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Annals of Human Genetics Pub Date : 2022-04-18 DOI:10.1111/ahg.12467

Jiarui Cui, Wei Peng, Ting Yi, Ping Gao, Mingze Zhou, Tianmin Zhu

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引用次数: 1

Abstract

Background

The circadian locomotor output cycles kaput (CLOCK) gene and the alcohol dehydrogenase 4 (ADH4) gene are promising candidates for susceptibility to cluster headaches (CH). Associations of the three single nucleotide polymorphisms (SNPs)—CLOCK SNP rs1801260 and ADH4 SNPs rs1800759, and rs1126671—with CH were studied previously, but the results were inconsistent.

Methods

Associations between the three SNPs (rs1801260, rs1126671, and rs1800759) and CH risk were separately assessed by pooled odds ratios (ORs) along with 95% confidence intervals (95% CIs) based on five different genetic models. Methodological quality was assessed using the Newcastle–Ottawa Quality Assessment Scale (NOS). All statistical analyses were carried out with RevMan 5.3 software.

Results

Eight studies involving 1437 CH patients and 2541 healthy controls were selected for quantitative synthesis, from five studies on CLOCK rs1801260, five on ADH4 rs1800759, and three on ADH4 rs1126671. Our pooled data did not support associations between the three SNPs (rs1801260 in the CLOCK gene, rs1800759 and rs1126671 in the ADH4 gene) and susceptibility to CH (rs1801260: OR 1.10, 95% CI: 0.95–1.28; p = 0.19; rs1800759: OR 1.06, 95% CI: 0.93–1.22; p = 0.37; and rs1126671: OR 1.09, 95% CI: 0.92–1.28; p = 0.32).

Conclusion

We found no significant associations between the three SNPs (rs1801260 in the CLOCK gene and rs1800759 and rs1126671 in the ADH4 gene) and the susceptibility to CH across both Caucasian and Asian ethnicities in our meta-analysis.

查看原文本刊更多论文

CLOCK和ADH4基因中的SNPs与丛集性头痛易感性之间没有显著关联：一项系统综述和荟萃分析

昼夜节律运动输出周期kaput（CLOCK）基因和乙醇脱氢酶4（ADH4）基因是丛集性头痛（CH）易感性的候选基因。三种单核苷酸多态性（SNPs）——CLOCK SNP rs1801260、ADH4 SNPs rs1800759和rs1126671——与CH的相关性先前曾进行过研究，但结果不一致。

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来源期刊

Annals of Human Genetics 生物-遗传学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.