Ephedra alata extracts exerts anti-obesity, anti-hyperglycemia, anti-antipyretic and analgesic effects

IF 1 Q4 FOOD SCIENCE & TECHNOLOGY

Nutrition & Food Science Pub Date : 2021-11-18 DOI:10.1108/nfs-03-2021-0086

Mohamed Tiss, Zoubeida Souiy, L. Achour, K. Hamden

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引用次数: 5

Abstract

Purpose This study paper aims to evaluate the Phytochemical Composition, anti-obesity, anti-antipyretic and analgesic effect of Ephedra alata (Ea) extracts. Design/methodology/approach Obesity was induced in male Wistar rats through a high-fat/fructose diet (HF/FD). Control rats received a standard diet. Findings Results of this study showed that the Ea methanol extract (MEEa) exhibited a prominent selective inhibitory effect against lipase activity (IC50 = 1.29 mg/ml) as compared to water and ethyl acetate extracts (with IC50 = 1.63 and 1.89, respectively). Also, MEEa exert antipyretic and analgesic activities. In high-fat-high-fructose diet rats, the administration of MEEa inhibited lipase activity in the intestine, pancreas and serum by 53%, 40% and 53%, respectively. It was found to significantly decrease body weight by 20% (p = 0.09) and delay the absorption of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDL-C) and increase HDL-cholesterol (HDL-C). In addition, MEEa efficiently decreased a-amylase activity in the intestine, pancreas and serum by 43%, 26% and 46%, respectively, and blood glucose level by 35% (p = 0.06). Originality/value To the best of the authors’ knowledge, this study demonstrates for the first time that MEEa are efficient in preventing obesity and hyperglycemia, pain and fever.

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麻黄提取物具有抗肥胖、抗高血糖、抗解热镇痛作用

目的评价麻黄素提取物的植物化学成分、抗肥胖、解热镇痛作用。设计/方法/方法通过高脂肪/果糖饮食（HF/FD）在雄性Wistar大鼠中诱导肥胖。对照大鼠接受标准饮食。本研究结果表明，Ea甲醇提取物（MEEa）对脂肪酶活性具有显著的选择性抑制作用（IC50=1.29 mg/ml）（IC50分别为1.63和1.89）。此外，MEEa还具有解热镇痛作用。在高脂肪高果糖饮食大鼠中，MEEa的给药对肠道、胰腺和血清中的脂肪酶活性分别抑制了53%、40%和53%。研究发现，它能显著降低20%的体重（p=0.09），并延迟甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）的吸收，增加高密度脂蛋白（HDL-C）。此外，MEEa有效地降低了肠道、胰腺和血清中的a-淀粉酶活性，分别降低了43%、26%和46%，血糖水平降低了35%（p=0.06）。原创/价值据作者所知，本研究首次证明MEEa在预防肥胖、高血糖、疼痛和发烧方面是有效的。

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来源期刊

Nutrition & Food Science FOOD SCIENCE & TECHNOLOGY-

CiteScore

2.80

自引率

8.30%

发文量

期刊介绍： Nutrition & Food Science* (NFS) is an international, double blind peer-reviewed journal offering accessible and comprehensive coverage of food, beverage and nutrition research. The journal draws out the practical and social applications of research, demonstrates best practice through applied research and case studies and showcases innovative or controversial practices and points of view. The journal is an invaluable resource to inform individuals, organisations and the public on modern thinking, research and attitudes to food science and nutrition. NFS welcomes empirical and applied research, viewpoint papers, conceptual and technical papers, case studies, meta-analysis studies, literature reviews and general reviews which take a scientific approach to the following topics: -Attitudes to food and nutrition -Healthy eating/ nutritional public health initiatives, policies and legislation -Clinical and community nutrition and health (including public health and multiple or complex co-morbidities) -Nutrition in different cultural and ethnic groups -Nutrition during pregnancy, lactation, childhood, and young adult years -Nutrition for adults and older people -Nutrition in the workplace -Nutrition in lower and middle income countries (incl. comparisons with higher income countries) -Food science and technology, including food processing and microbiological quality -Genetically engineered foods -Food safety / quality, including chemical, physical and microbiological analysis of how these aspects effect health or nutritional quality of foodstuffs