Antioxidant Potential of Caesalpenia Bonducella Seeds in the Management of Polycystic Ovary Syndrome (PCOS) Using Mifepristone Induced Rats Model

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2020-07-18 DOI:10.1080/10496475.2020.1795041

B. Meera, P. Muralidharan, R. Hari

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引用次数: 3

Abstract

ABSTRACT The effects of ethanolic seed extract of Caesalpenia bonducella (ESECB) on in vivo enzymatic and non-enzymatic antioxidant levels and histopathological changes in Mifepristone-induced polycystic ovary syndrome (PCOS) female rats were evaluated. PCOS-induced rats were treated with ESECB at 200 mg and 400 mg kg−1 b.w. p.o. for 28 d. Metformin 20 mg kg−1 b.w. was used as a standard drug. At the end of the experimental period, blood was collected from all rats for the estimation of enzymatic and non-enzymatic antioxidants. Ovaries were used for the histopathological analysis. In rats treated with Mifepristone, there was a decrease in the antioxidant enzymes catalase, super oxide dismutase, glutathione peroxidase, glutathione – S – transferase and glutathione reductase, which increased in the ESECB-treated groups. The altered levels of non-enzymatic antioxidants were also brought back to normal levels in these groups. Histopathology showed that the ESECB-treated rats regained normal physiology of ovarian architecture, which was distorted due to the PCOS condition.

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米非司酮诱导大鼠多囊卵巢综合征（PCOS）大鼠模型中邦杜氏Caesalpenia Bonducella种子的抗氧化能力

摘要:本研究探讨了黄花籽醇提物(ESECB)对米非司酮诱导的多囊卵巢综合征(PCOS)雌性大鼠体内酶促和非酶促抗氧化水平及组织病理学变化的影响。pcos诱导大鼠分别给予ESECB 200 mg和400 mg kg - 1 b.w.，连续28 d。以二甲双胍20 mg kg - 1 b.w.作为标准药。在实验结束时，收集所有大鼠的血液，用于评估酶促和非酶促抗氧化剂的含量。采用卵巢进行组织病理学分析。米非司酮组大鼠抗氧化酶过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽- S -转移酶和谷胱甘肽还原酶均降低，esecb组升高。在这些组中，非酶抗氧化剂的变化水平也恢复到正常水平。组织病理学结果显示，经esecb处理的大鼠卵巢结构恢复了正常的生理机能，卵巢结构因PCOS而扭曲。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.