3D printing of layered mesoporous bioactive glass/sodium alginate-sodium alginate scaffolds with controllable dual-drug release behaviors

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2019-10-03 DOI:10.1088/1748-605X/ab4166

Shengyang Fu, Xiaoyu Du, Min Zhu, Z. Tian, Daixu Wei, Yufang Zhu

引用次数: 24

Abstract

Scaffolds with controlled drug release are valuable for bone tissue engineering, but constructing the scaffolds with controllable dual-drug release behaviors is still a challenge. In this study, layered mesoporous bioactive glass/sodium alginate-sodium alginate (MBG/SA–SA) scaffolds with controllable dual-drug release behaviors were fabricated by 3D printing. The porosity and compressive strength of three-dimensional (3D) printed MBG/SA–SA scaffolds by cross-linking are about 78% and 4.2 MPa, respectively. As two model drugs, bovine serum albumin (BSA) and ibuprofen (IBU) were separately loaded in SA layer and MBG/SA layer, resulting in a relatively fast release of BSA and a sustained release of IBU. Furthermore, layered MBG/SA–SA scaffolds were able to stimulate human bone mesenchymal stem cells (hBMSCs) adhesion, proliferation and osteogenic differentiation than SA scaffolds. Hence, the 3D printed MBG/SA–SA scaffolds would be prospective for the treatment of bone defects.

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具有可控双药释放行为的层状介孔生物活性玻璃/海藻酸钠-海藻酸钠支架的3D打印

药物可控释放支架在骨组织工程中具有重要的应用价值，但构建具有可控双药释放行为的支架仍是一个挑战。本研究采用3D打印技术制备了具有可控双药释放行为的层状介孔生物活性玻璃/海藻酸钠-海藻酸钠(MBG/ SA-SA)支架。交联三维打印MBG/ SA-SA支架的孔隙率和抗压强度分别约为78%和4.2 MPa。牛血清白蛋白(BSA)和布洛芬(IBU)作为两种模型药物分别加载在SA层和MBG/SA层中，导致BSA的释放相对较快，IBU的释放持续。此外，层状MBG/SA - SA支架比SA支架更能刺激人骨间充质干细胞(hBMSCs)的粘附、增殖和成骨分化。因此，3D打印MBG/ SA-SA支架在骨缺损的治疗中具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters