Status vitamin D in Ukraine patients with Grave’s Disease

Abstract

Background: Vitamin D, immunological parameters, and thyroid function. Objective: Study the effect of vitamin D on immunological parameters and thyroid function. Patients and Methods: The open-label controlled study included 102 patients with moderate Grave’s disease (GD) who applied to the consulting clinic of the Institute of Endocrinology and Metabolism. VP Komissarenko NAMS of Ukraine “in the period 2018-2020. The control group included 42 people without thyroid pathology. immunochemiluminescent determination of 25(OH)D, antibodies to receptor TSH and TPO, radioimmune determination of thyroid hormones, ultrasound examination of the thyroid gland. Results: The level of vitamin D, determined by metabolite 25 (OH) D, in the serum of patients was significantly reduced compared to control. With age, vitamin D deficiency increased. At the age of 19-29.9 years the median was 59.1, at the age 30-49.9 – 47.0, at the age 50-65 years – 26,1 nmol / l. At the same time, an increase in the content of antibodies to thyroid-stimulating hormone in the blood serum was found. During treatment with tyrosol, along with a decrease in thyroid function, a decrease in the level of TSH Ab was observed. Complex treatment with tyrosol and vitamin D contributed to an even greater decrease in the level of TSH Ab. There was increase in TSH levels after 3 months. and a significant reduction volume thyroid after 6 months treatment. Conclusion: The use of vitamin D in the treatment of GD with tyrosol for 3-6 months reduces the level of TSH Ab, volume thyroid and increases the level of TSH.