Optimization of 3D Printing Parameters of Polylactic-Co-Glycolic Acid-Based Biodegradable Antibacterial Materials Using Fused Deposition Modeling.

Abstract

A high incidence of ureteral diseases was needed to find better treatments such as implanting ureteral stents. The existing ureteral stents produced a series of complications such as bacterial infection and biofilm after implantation. The fused deposition modeling (FDM) of 3D printing biodegradable antibacterial ureteral stents had gradually become the trend of clinical treatment. But it was necessary to optimize the FDM 3D printing parameters of biodegradable bacteriostatic materials to improve the precision and performance of manufacturing. In this study, polylactic-co-glycolic acid (PLGA), polycaprolactone (PCL), and nanosilver (AgNP) were mixed by the physical blending method, and the 3D printing parameters and properties were studied. The relationship between printing parameters and printing errors was obtained by single-factor variable method and linear fitting. The performance of 3D printing samples was obtained through infrared spectrum detection, molecular weight detection, and mechanical testing. The printing temperature and the printing pressure were proportional to the printing error, and the printing speed was inversely proportional to the printing error. The 3D printing has little effect on the functional groups and molecular weights of biodegradable antibacterial materials. The addition of AgNP increases the compressive strength and breaking strength by 8.332% and 37.726%, which provided ideas for regulating the mechanical properties. The parameter range of biodegradable bacteriostatic materials for thermal melting 3D printing was precisely established by optimizing the parameters of printing temperature, printing pressure, and printing speed, which would be further applied to the advanced manufacturing of biodegradable implant interventional medical devices.