Eosinophilic esophagitis—from definition to therapy

Q3 Medicine
Ulrike von Arnim
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Abstract

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder that is characterized clinically by symptoms of esophageal dysfunction and histologically by a dense eosinophilic inflammation of the esophagus. This article provides an overview of the current knowledge in the field of EoE. EoE has seen significant progress in its understanding, including its definition, clinical presentation, diagnosis, and treatment. Consensus criteria have been established for diagnosing EoE, with symptoms commonly including dysphagia, food impaction, and reflux-like symptoms. Diagnosis involves clinical evaluation, endoscopy, and histological assessment. Therapeutic strategies for EoE aim to alleviate symptoms, induce and maintain remission, and prevent complications. These strategies include dietary modifications, pharmacotherapy, and endoscopic interventions. Treatment choice depends on disease severity, patient preferences, and comorbidities. Despite progress, challenges persist in EoE management. Long-term outcomes and optimal treatment duration are still under investigation. Research efforts focus on identifying predictive markers for treatment response and developing personalized approaches. In conclusion, EoE is a chronic, progressive and recurrent disease with various clinical manifestations and treatment options. Improved understanding has led to better diagnostic criteria and therapeutic strategies. However, further research is necessary to enhance our understanding of disease pathogenesis, refine treatment algorithms, and optimize long-term outcomes for individuals with EoE.

嗜酸性食管炎——从定义到治疗
嗜酸性粒细胞食管炎(EoE)是一种由免疫介导的慢性疾病,临床上以食管功能障碍症状为特征,组织学上以食管致密的嗜酸性粒细胞炎症为特征。本文概述了食管炎领域的现有知识。人们对食管水肿的认识取得了重大进展,包括其定义、临床表现、诊断和治疗。诊断胃食管返流的共识标准已经确立,症状通常包括吞咽困难、食物嵌塞和反流样症状。诊断包括临床评估、内窥镜检查和组织学评估。肠易激综合征的治疗策略旨在减轻症状、诱导和维持缓解以及预防并发症。这些策略包括饮食调整、药物治疗和内窥镜干预。治疗方法的选择取决于疾病的严重程度、患者的偏好和合并症。尽管取得了进展,但在治疗咽喉炎方面仍存在挑战。长期疗效和最佳治疗时间仍在研究之中。研究工作的重点是确定治疗反应的预测标志物和开发个性化方法。总之,肠易激综合征是一种慢性、进展性和复发性疾病,具有各种临床表现和治疗方案。随着对该病认识的加深,诊断标准和治疗策略也在不断完善。然而,我们还需要开展进一步的研究,以加强对疾病发病机制的了解、完善治疗算法并优化咽喉炎患者的长期疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Allergo Journal International
Allergo Journal International Medicine-Immunology and Allergy
CiteScore
4.60
自引率
0.00%
发文量
31
期刊介绍: Allergo Journal International is the official Journal of the German Society for Applied Allergology (AeDA) and the Austrian Society for Allergology and Immunology (ÖGAI). The journal is a forum for the communication and exchange of ideas concerning the various aspects of allergy (including related fields such as clinical immunology and environmental medicine) and promotes German allergy research in an international context. The aim of Allergo Journal International is to provide state of the art information for all medical and scientific disciplines that deal with allergic, immunological and environmental diseases. Allergo Journal International publishes original articles, reviews, short communications, case reports, and letters to the editor. The articles cover topics such as allergic, immunological and environmental diseases, the latest developments in diagnosis and therapy as well as current research work concerning antigens and allergens and aspects related to occupational and environmental medicine. In addition, it publishes clinical guidelines and position papers approved by expert panels of the German, Austrian and Swiss Allergy Societies. All submissions are reviewed in single-blind fashion by at least two reviewers. Originally, the journal started as a German journal called Allergo Journal back in 1992. Throughout the years, English articles amounted to a considerable portion in Allergo Journal. This was one of the reasons to extract the scientific content and publish it in a separate journal. Hence, Allergo Journal International was born and now is the international continuation of the original German journal. Nowadays, all original content is published in Allergo Journal International first. Later, selected manuscripts will be translated and published in German and included in Allergo Journal.
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