The relationship between hemoglobin variability and oxidative stress and inflammation in CKD

Journal of Clinical and Analytical Medicine Pub Date : 2019-01-01 DOI:10.4328/jcam.5912

T. Kus

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引用次数: 1

Abstract

DOI: 10.4328/JCAM.5912 Received: 26.05.2018 Accepted: 09.06.2018 Published Online: 10.06.2018 Printed: 01.01.2019 J Clin Anal Med 2019;10(1): 20-5 Corresponding Author: Tulay Kus, Department of Medical Oncology, Adıyaman University, Training and Research Hospital, TR-02040, Adıyaman, Turkey. T.: +90 4162161015 F.: +90 4162161014 E-Mail: drtulaykus83@hotmail.com Abstract Aim: Hemoglobin (Hg) variability, which is frequently seen in patients with chronic kidney disease (CKD) who undergo dialysis, has been shown to be associated with increased mortality and cardiovascular disease (CVD) , but its mechanism remains unclear. Increased oxidative stress and inflammation with uremia lead to the development of anemia. In this context, we aimed to investigate the relationship between Hb variability and oxidative stress and inflammation. Material and Method: The data of 114 patients followed by dialysis service of Gaziantep University were included in this study retrospectively. Myeloperoxidase (MPO), nitrotyrosine (NTY), total antioxidant capacity (TAC), interleukin-6 (IL-6), Hs-CRP, and plasminogen activator inhibitor-1(PAI-1) levels of the patients whom we divided into 6 groups according to their Hg variability were measured. A control group (n = 30) was also formed demographically and clinically appropriate to this group. Results: The mean MPO, NTY, IL-6, Hs-CRP, and PAI-1 levels were higher in the dialysis patients than in the control group, whereas TAC levels were lower. Prooxidant, inflammation and procoagulant activity levels were lower in the Group 6 (Hg>12) and the Group 3 (stable, Hg=11-12 gr/dl) but higher in wide Hg variable group (Group 5) and Group 1 (Hg <12 gr/dl). Discussion: Oxidative stress, inflammation, and procoagulant activity, which are associated with higher CVD and mortality were found to be high in wide Hg variable and anemic groups in patients who underwent dialysis. The present study has a valuable finding in terms of elucidating the possible mechanism of increased mortality in patients with wide variable Hg course.

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慢性肾病中血红蛋白变异与氧化应激和炎症的关系

DOI: 10.4328 / JCAM.5912收稿日期:26.05.2018收稿日期:09.06.2018出版日期:10.06.2018印刷日期:01.01.2019 J clinin Anal Med 2019;10(1): 20-5通讯作者:Tulay Kus, Adıyaman大学，培训与研究医院，TR-02040, Adıyaman，土耳其肿瘤内科。摘要目的:血红蛋白(Hg)变异性，常见于接受透析的慢性肾脏疾病(CKD)患者，已被证明与死亡率增加和心血管疾病(CVD)相关，但其机制尚不清楚。氧化应激和炎症的增加与尿毒症导致贫血的发展。在这种情况下，我们旨在研究Hb变异性与氧化应激和炎症之间的关系。材料与方法:回顾性分析加济安泰普大学透析科114例患者的资料。测定髓过氧化物酶(MPO)、硝基酪氨酸(NTY)、总抗氧化能力(TAC)、白细胞介素-6 (IL-6)、Hs-CRP和纤溶酶原激活物抑制剂-1(PAI-1)水平。另设人口统计学和临床统计学上与该组相适应的对照组(n = 30)。结果:透析组患者MPO、NTY、IL-6、Hs-CRP、PAI-1水平均高于对照组，TAC水平低于对照组。抗氧化、炎症和促凝活性水平在6组(Hg bbb12)和3组(稳定，Hg=11-12 gr/dl)中较低，但在宽汞可变组(5组)和1组(Hg <12 gr/dl)中较高。讨论:氧化应激、炎症和促凝活性与较高的心血管疾病和死亡率相关，在接受透析的患者中，在宽汞变量组和贫血组中被发现较高。本研究有一个有价值的发现，在阐明可能的机制，增加死亡率的患者可变宽汞病程。

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Journal of Clinical and Analytical Medicine MEDICINE, GENERAL & INTERNAL-

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期刊介绍： The Annals of Clinical and Analytical Medicine is an international open-access journal containing peer-reviewed high-quality articles on clinical medicine in the areas of all research study types, reviews, and case reports. Our journal has become an important platform with the help of language support services, which make it easier for writers who have English as their second language to share their clinical experiences with the world.