A transomic cohort as a reference point for promoting a healthy human gut microbiome

Q2 Medicine

Medicine in Microecology Pub Date : 2021-06-01 DOI:10.1016/j.medmic.2021.100039

Zhuye Jie , Suisha Liang , Qiuxia Ding , Fei Li , Shanmei Tang , Dan Wang , Yuxiang Lin , Peishan Chen , Kaiye Cai , Xuemei Qiu , Qiang Li , Yunli Liao , Dongsheng Zhou , Heng Lian , Yong Zuo , Xiaomin Chen , Weiqiao Rao , Yan Ren , Yuan Wang , Jin Zi , Xun Xu

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引用次数: 11

Abstract

More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.

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跨体队列作为促进健康人类肠道微生物组的参考点

十多年来对肠道微生物组的研究都有一个共同的目标，那就是改善人类健康。然而，虽然大多数疾病研究都集中在老年人或中年人身上，但缺乏年轻人肠道微生物组的参考队列。为了更好地了解肠道微生物群，还需要测量哪些组学数据，目前还不清楚。在这里，我们提出了一个包括2183名成年人的队列，具有粪便微生物组和其他组学数据的高深度宏基因组霰弹枪测序数据。在这个多组组队列中，我们观察到许多维生素、激素、氨基酸和微量元素与肠道微生物组相关。许多关联在另外一个由1404人组成的队列中得到了验证。我们的综合数据准备为未来的人群和机械研究设计提供建议，以更好地理解和管理我们的肠道微生物群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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