Zeqing Jin , Grace Hu , Zhizhou Zhang , Shao-Yi Yu , Grace X. Gu
{"title":"Modeling and analysis of post-processing conditions on 4D-bioprinting of deformable hydrogel-based biomaterial inks","authors":"Zeqing Jin , Grace Hu , Zhizhou Zhang , Shao-Yi Yu , Grace X. Gu","doi":"10.1016/j.bprint.2023.e00286","DOIUrl":null,"url":null,"abstract":"<div><p><span><span><span>Deformable structures have been actively developed for several biomedical applications<span><span><span> including drug delivery and tissue engineering using 3D-bioprinting methods. However, structural shape-transformation usually consists of a series of </span>bending behaviors in response to external stimuli, which require complex aggregation and multi-materials design. To overcome these complexities, this work explores an alternative approach using only a single hydrogel-based material to realize such bending mechanisms. Numerical simulations are first implemented to realize </span>bending deformation by spatially assigning distinct material parameters to different sections of the structure. The bending phenomenon is also shown experimentally using hydrogel-based biomaterial inks. Specifically, a deformable structure is fabricated by finely controlling different post-processing conditions such as cooling time, crosslinking duration, and heating rate during swelling to mimic the effect of different material parameters. Moreover, the bending deformation can be further analyzed using </span></span>computer vision<span> methods to inversely determine the desired material coefficients in the simulation. Relationships among bending mechanisms, material parameters, and post-processing procedures are found and shown to affect the final bending orientation. These results yield insightful approaches to the inverse design of functional </span></span>biomedical devices with desired </span>deformation behavior.</p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000295","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 0
Abstract
Deformable structures have been actively developed for several biomedical applications including drug delivery and tissue engineering using 3D-bioprinting methods. However, structural shape-transformation usually consists of a series of bending behaviors in response to external stimuli, which require complex aggregation and multi-materials design. To overcome these complexities, this work explores an alternative approach using only a single hydrogel-based material to realize such bending mechanisms. Numerical simulations are first implemented to realize bending deformation by spatially assigning distinct material parameters to different sections of the structure. The bending phenomenon is also shown experimentally using hydrogel-based biomaterial inks. Specifically, a deformable structure is fabricated by finely controlling different post-processing conditions such as cooling time, crosslinking duration, and heating rate during swelling to mimic the effect of different material parameters. Moreover, the bending deformation can be further analyzed using computer vision methods to inversely determine the desired material coefficients in the simulation. Relationships among bending mechanisms, material parameters, and post-processing procedures are found and shown to affect the final bending orientation. These results yield insightful approaches to the inverse design of functional biomedical devices with desired deformation behavior.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.