Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2019-12-05 DOI:10.1088/1748-605X/ab5f1a

G. Molino, M. Palmieri, Giorgia Montalbano, S. Fiorilli, C. Vitale-Brovarone

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引用次数: 47

Abstract

In the last decades, many research groups have experimented the synthesis of hydroxyapatite (HA) for bone tissue application obtaining products with different shapes and dimensions. This review aims to summarise and critically analyse the most used methods to prepare physiologic-like nano-HA, in the form of plates or rods, similar to the HA present in the human bones. Moreover, mesoporous HA has gained increasing interest in the biomedical field due its pecualiar structural features, such as high surface area and accessible mesoporous volume, which is known to confer enhanced biological behaviour and the possibility to act as nanocarriers of functional agents for bone-related therapies. For this reason, more recent studies related to the synthesis of mesoporous HA, with physiological-like morphology, are also considered in this review. Since a wide class of surfactant molecules plays an essential role both in the shape and size control of HA crystals and in the formation of mesoporosity, a section devoted to the mechanisms of action of several surfactants is also provided.

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仿生和介孔纳米羟基磷灰石在骨组织中的应用综述

在过去的几十年里，许多研究小组进行了合成羟基磷灰石(HA)用于骨组织应用的实验，获得了不同形状和尺寸的产品。这篇综述的目的是总结和批判性地分析最常用的制备生理类纳米透明质酸的方法，以板或棒的形式，类似于人类骨骼中的透明质酸。此外，由于其特殊的结构特征，如高表面积和可接近的介孔体积，介孔透明质酸在生物医学领域获得了越来越多的兴趣，这被认为可以增强生物行为，并有可能作为骨相关治疗功能剂的纳米载体。因此，本综述也考虑了最近有关合成具有生理样形态的介孔透明质酸的研究。由于种类繁多的表面活性剂分子在透明质酸晶体的形状和大小控制以及介孔的形成中起着至关重要的作用，因此还提供了一节专门讨论几种表面活性剂的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters

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