The effect of milk thistle, metiphen, and silimevit on the protein-synthesizing function of the liver of laying hens in experimental chronic cadmium toxicosis

Abstract

The study aimed to investigate the effect of milk thistle, methiphene, and silimevit on the liver's protein-synthesizing function of laying hens in examination chronic cadmium toxicosis. Thirty-two chickens, 78 weeks old, were selected for the study. Four groups were formed: control and three experimental. Birds of the experimental group (E1) with fodder were fed the fruits of milk thistle at a dose of 2.0 g/kg of feed once a day for 30 days. Chickens of the experimental group (E2) were fed metifen at a dose of 0.28 g / kg of nutrition once a day for 30 days. Hens of the experimental group (E3) were fed silymevit at a dose of 0.36 g/kg of feed nutrition once a day for 30 days. The results showed that the total protein content and its plasma fractions of birds vary throughout the research in poultry control and experimental groups. Thus, in the blood of laying hens subjected to cadmium loading, a decrease in their blood of total protein and albumin fraction was found. Under the cadmium toxicosis of chickens, milk thistle, metifen, and silimevit positively affect the liver's protein-synthesizing function, as indicated by an increase in the total protein level and albumin. Feeding with milk thistle and silymevit contributed to a better normalizing effect on the liver's protein-synthesizing function than the use of metifen.