Prenatal exposure of diclofenac sodium alters the behavioral development of young Wistar rats

IF 1.1 4区 生物学 Q3 BIOLOGY
B. Elibol, Begüm ARITAN OĞUR, H. Doğru
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引用次数: 1

Abstract

Diclofenac sodium (DS), a potent inhibitor of cyclooxygenase, reduces the release of arachidonic acid and formation of prostaglandins. Being a nonsteroid drug that shows antiinflammatory action, the possible side effects of fetal DS administration gain importance in public and medical applications. Herein, the effects of DS administration (1 mg/kg) during gestational days 5–20 were investigated on the performance of Wistar rat pups in a variety of behavioral tasks. Four-week-old pups were subjected to sensory motor tests, a plus maze, an open field, the Morris water maze, and a radial arm maze. Fetal DS disrupted some sensory motor performances, such as visual placing and climbing in both females and males. In the open field, DS females had a higher level of anxiety and male DS pups habituated to the environment slowly compared to controls. The DS pups showed slower rates of learning, whereas no substantial between-group differences were found in the performance of spatial memory compared to both controls. Furthermore, working memory was negatively affected by fetal DS. In conclusion, it was indicated that DS administration during pregnancy had slight behavioral impacts with a delay in learning and a defect in the short-term memory in juvenile rats.
产前接触双氯芬酸钠对幼龄Wistar大鼠行为发育的影响
双氯芬酸钠(DS)是一种有效的环氧合酶抑制剂,可减少花生四烯酸的释放和前列腺素的形成。作为一种具有抗炎作用的非甾体药物,胎儿DS给药可能产生的副作用在公共和医学应用中越来越重要。在此,研究了妊娠第5-20天DS给药(1 mg/kg)对Wistar大鼠幼崽在各种行为任务中表现的影响。四周大的幼崽接受了感觉运动测试、加号迷宫、开阔地、莫里斯水迷宫和桡臂迷宫。胎儿DS破坏了一些感觉运动表现,如女性和男性的视觉定位和攀爬。在开阔地里,与对照组相比,雌性DS幼崽的焦虑程度更高,雄性DS幼崽对环境的适应速度较慢。DS幼崽的学习速度较慢,而与两个对照组相比,在空间记忆表现方面没有发现显著的组间差异。此外,工作记忆受到胎儿DS的负面影响。总之,研究表明,妊娠期服用DS对幼年大鼠的行为影响很小,学习延迟,短期记忆有缺陷。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: The Turkish Journal of Biology is published electronically 6 times a year by the Scientific and Technological Research Council of Turkey (TÜBİTAK) and accepts English-language manuscripts concerning all kinds of biological processes including biochemistry and biosynthesis, physiology and metabolism, molecular genetics, molecular biology, genomics, proteomics, molecular farming, biotechnology/genetic transformation, nanobiotechnology, bioinformatics and systems biology, cell and developmental biology, stem cell biology, and reproductive biology. Contribution is open to researchers of all nationalities.
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