Genome-wide association study for heat stress resistance in Brown Swiss cattle in Yucatan, Mexico

IF 0.5 4区农林科学 Q4 VETERINARY SCIENCES

Veterinaria Mexico Pub Date : 2023-05-08 DOI:10.22201/fmvz.24486760e.2023.1137

Sandra Giovanna Nuñez Soto, José Manuel Berruecos Villalobos, Nelson Cala Moreno, J. G. Magaña Monforte, P. Ochoa Galván, Raúl Ulloa Arvisu, Hugo O. Toledo Alvarado

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引用次数: 0

Abstract

Global climate change has made heat stress tolerance an important trait to be considered in breeding programs to improve the resistance of productive animals to unfavorable environmental conditions. The aim of this study was to know the association between single nucleotide polymorphism (SNP) markers and heat stress resistance through a genome-wide association study (GWAS). Where 95 Brown Swiss dairy cows have measured body temperatures, respiratory frequencies, and genotypes. Seven SNP were detected with a statistically significant effect (P < 0.01) on respiratory frequency under heat stress. The markers with the highest association are in the Bos taurus autosome 6 (BTA 6), e.g. the BovineHD0600010397 SNP located within the FAM13A gene, and the BovineHD0600012612 SNP located within the PI4K2B gene. The ARS-BFGL-NGS-102407 SNP that is located in BTA 4 is the SNP that presents the highest number of associations to genes. Most of the genes are involved in cellular processes that are present in the resistance of individuals to high and humid environmental temperatures. These results provide new insights into the genetics of heat stress tolerance in Brown Swiss cattle in Yucatan, Mexico.

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墨西哥尤卡坦棕色瑞士牛耐热性的全基因组关联研究

全球气候变化使耐热性成为育种计划中需要考虑的一个重要特征，以提高生产性动物对不利环境条件的抵抗力。本研究的目的是通过全基因组关联研究（GWAS）了解单核苷酸多态性（SNP）标记物与热应激抗性之间的关系。其中95头棕色瑞士奶牛测量了体温、呼吸频率和基因型。检测到7个SNP对热应激下的呼吸频率有统计学意义（P<0.01）。具有最高关联性的标记物在牛牛常染色体6（BTA 6）中，例如位于FAM13A基因内的Bovine HD0600010397 SNP和位于PI4K2B基因内的bovine HD6060012612 SNP。位于BTA4中的ARS-BFGL-NGS-102407 SNP是与基因相关数量最多的SNP。大多数基因参与细胞过程，这些过程存在于个体对高湿环境温度的抵抗中。这些结果为墨西哥尤卡坦棕色瑞士牛耐热性的遗传学提供了新的见解。

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来源期刊

Veterinaria Mexico Veterinary-General Veterinary

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Veterinaria México OA (ISSN 2448-6760) is an online scientific journal edited by Universidad Nacional Autónoma de México (UNAM). The journal is Open Access and follows UNAM''s initiative, to transmit knowledge free of charge to the readership and authors, with no Article Processing Charges. This journal publishes advances in Veterinary Sciences and Animal Production, and to reach more lectures across the world the journal was updated since 2014 from its predecessor printed in paper Veterinaria México (ISSN 0301-5092) and its digital version (ISSN 2007-5472).