Silent Coronary Artery Disease in Patients with Rheumatoid Arthritis in Kurdistan, Iraq: A cross-sectional study

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Journal of Contemporary Medical Sciences Pub Date : 2023-04-26 DOI:10.22317/jcms.v9i2.1339

Ameen M Mohammad, Malavan H. Mohammed, Mohammed T Rasul, Azri Salih Sgery

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Abstract

Objectives: This study attempts to determine the silent coronary artery disease (CAD) in a sample of Iraqi Kurdish patients diagnosed with rheumatoid arthritis (RA). Methods: A total of 50 such patients from Duhok, Kurdistan region of Iraq, underwent multi slices computed tomography (MSCT) coronary angiography 64 slices to determine coronary artery calcium (CAC) scores and coronary stenoses. Results: 62% of cases had a (CAC) score > zero on non-contrast MSCT scans. Coronary angiograms showed that 26 (52%) of the cases had variable coronary artery stenosis; 17(34%) of them were obstructive (>50% luminal narrowing). The study demonstrated that Inflammatory markers (rheumatoid factor, Anti- cyclic citrullinated peptides, and some cardiovascular risk factors, namely (hypertension and type 2 diabetes mellitus) were significantly related to the presence of CAD in these patients. Conclusions: Patients with rheumatoid arthritis are at increased risk of CAD. This risk is higher in the presence of inflammatory and cardiovascular risk factors.

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伊拉克库尔德斯坦地区类风湿关节炎患者无症状冠状动脉疾病:一项横断面研究

目的：本研究试图在一名被诊断为类风湿性关节炎（RA）的伊拉克库尔德患者样本中确定无症状冠状动脉疾病（CAD）。方法：对来自伊拉克库尔德斯坦地区Duhok的50例此类患者进行64层多层计算机断层扫描（MSCT）冠状动脉造影，以测定冠状动脉钙（CAC）评分和冠状动脉狭窄程度。结果：62%的病例在非对比MSCT扫描中（CAC）得分>零。冠状动脉造影显示，26例（52%）患者存在可变冠状动脉狭窄；其中17例（34%）为梗阻性（＞50%管腔狭窄）。研究表明，炎症标志物（类风湿因子、抗环瓜氨酸肽和一些心血管风险因素，即高血压和2型糖尿病）与这些患者的CAD存在显著相关。结论：类风湿性关节炎患者患冠心病的风险增加。在存在炎症和心血管危险因素的情况下，这种风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Contemporary Medical Sciences MEDICINE, GENERAL & INTERNAL-

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审稿时长

12 weeks