Comparative analyses of the complete mitochondrial genomes of the two filarial worms Wuchereria bancrofti & Brugia malayi with Caenorhabditis elegans

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Integrated OMICS Pub Date : 2022-10-03 DOI:10.5584/jiomics.v12i1.212

Saranya Joshi, Lokesh Kumar, K. Rauthan, Sudhir Kumar

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Abstract

Wuchereria bancrofti and Brugia malayi are the filarial worms belonging to phylum Nematoda and cause lymphatic filariasis (LF) disease in humans. W. bancrofti and B. malayi are Wolbachia dependent organisms while C. elegans is free living Wolbachia independent nematode. In order to investigate the conserved regions present in the mitochondrial genome of these organisms, the complete mitochondrial (mt) genomes of W. bancrofti and B. malayi having size 13,636 bp and 13,657 bp in length, respectively are compared with C. elegans (13794 bp). These mt genomes were similar to each other in respect of their size, AT content and encode the same 12 PCGs (nad1–6, nad4L, cytb, cox1–3, and atp6). Complete mt genome alignment identified 13 conserved regions in each of the organisms with some of these regions unique only to one organism. Phylogenetic analysis using the mt genome showed a close relationship between W. bancrofti and B. malayi but showed a common early ancestor with the C. elegans emphasizing an early evolutionary divergence.

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bancrofti和马来丝虫与秀丽隐杆线虫线粒体全基因组的比较分析

班氏丝虫和马来丝虫是线虫门的丝虫，可引起人类淋巴丝虫病。bancrofti和马来王是沃尔巴克氏体依赖性生物，而秀丽隐杆线虫是自由生活的沃尔巴克氏氏体独立线虫。为了研究这些生物的线粒体基因组中存在的保守区域，将班克罗夫特和马来王的完整线粒体（mt）基因组（大小分别为13636bp和13657bp）与秀丽隐杆线虫（13794bp）进行了比较。这些mt基因组在大小、AT含量方面彼此相似，并编码相同的12个PCG（nad1-6、nad4L、cytb、cox1-3和atp6）。完整的mt基因组比对确定了每个生物体中的13个保守区域，其中一些区域仅为一个生物体所特有。使用mt基因组进行的系统发育分析显示，班克罗夫提和马来王之间关系密切，但与秀丽隐杆线虫有一个共同的早期祖先，强调了早期进化的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Integrated OMICS Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.