Expression of kinesin family member C1 in hepatocellular carcinoma and its correlation with prognosis and clinicopathological features

国际生物医学工程杂志 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1673-4181.2019.06.006

Yi Liu, Hua Fan, Huihui Wang, B. Zhang, Jing-ming Zhai, Yonggang Fan

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Abstract

Objective To study the expression of kinesin family member C1 (KIFC1) in hepatocellular carcinoma (HCC) and analyze its correlation with the clinicopathological features and prognosis of patients. Methods The expression levels of KIFC1 protein in the HCC tissues from 82 patients were determined by immunohistochemical staining. The correlation between KIFC1 protein and clinicopathological characteristics (including age, gender, tumor nodules, tumor grade, tumor volume, lymph node metastasis, and alpha-fetoprotein expression) was analyzed. The Kaplan-Meier analysis was used to analyze the effect of KIFC1 expression level on overall survival and progression-free survival in patients with HCC. The expression level of KIFC1 mRNA in liver cancer tissue was analyzed by GPEIA database. The correlation between KIFC1 expression and prognosis was analyzed by KM-plotter. Results KIFC1 protein is significantly overexpressed in liver cancer tissues, and its expression level is significantly correlated with tumor nodule number (P=0.023) and tumor size (P=0.011). Patients with high expression of KIFC1 had poor overall disease and disease-free survival (all P<0.05). KIFC1 mRNA is significantly overexpressed in liver cancer tissues and correlated with disease-free survival and overall survival. Conclusions The expression of KIFC1 protein is highly expressed in liver cancer tissues, and its expression level is related to the clinicopathological characteristics of liver cancer. Bioinformatics analysis results show that KIFC1 is related to the poor prognosis of patients, suggesting that KIFC1 is expected to be a potential predictor and therapeutic target for liver cancer prognosis. Key words: Hepatocellular carcinoma; Kinesin family member C1; Immunohistochemistry; Clinicopathological features; Prognosis

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激酶家族成员C1在肝细胞癌中的表达及其与预后和临床病理特征的关系

目的研究驱动蛋白家族成员C1（KIFC1）在肝细胞癌（HCC）中的表达，并分析其与患者临床病理特征和预后的关系。方法应用免疫组织化学方法检测82例HCC组织中KIFC1蛋白的表达水平。分析KIFC1蛋白与临床病理特征（包括年龄、性别、肿瘤结节、肿瘤分级、肿瘤体积、淋巴结转移和甲胎蛋白表达）之间的相关性。Kaplan-Meier分析用于分析KIFC1表达水平对HCC患者总生存率和无进展生存率的影响。用GPEIA数据库分析了肝癌组织中KIFC1mRNA的表达水平。用KM绘图仪分析KIFC1表达与预后的相关性。结果KIFC1蛋白在癌症组织中显著表达，其表达水平与肿瘤结节数（P=0.023）和肿瘤大小（P=0.011）显著相关，KIFC1mRNA在癌症组织中显著表达，与无病生存率和总生存率相关。结论KIFC1蛋白在癌症组织中高表达，其表达水平与癌症的临床病理特征有关。生物信息学分析结果表明，KIFC1与患者预后不良有关，提示KIFC1有望成为癌症预后的潜在预测因子和治疗靶点。关键词：肝细胞癌；Kinesin家族成员C1；免疫组织化学；临床病理特征；预后

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国际生物医学工程杂志

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1974