Automated Computerized Neuropsychological Diagnostics in Multiple Sclerosis

IF 0.5 4区心理学 Q4 CLINICAL NEUROLOGY

Zeitschrift Fur Neuropsychologie Pub Date : 2022-09-01 DOI:10.1024/1016-264x/a000359

Sascha Hansen, Lena Wettinger, Jana Keune, P. Oschmann, Philipp M. Keune

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Abstract

Abstract: Cognitive deficits are common in multiple sclerosis (MS), necessitating diagnosis and constant monitoring. However, frequent neuropsychological assessments are costly and not always feasible. A computerized assessment of basic cognitive functions could contribute to better patient care in this regard. The primary cognitive inventory of the Memory and Attention Test (MAT-COBI) constitutes such a tool. In this feasibility study, we tested N = 44 patients with MS with a standardized neuropsychological assessment consisting of established screening procedures (Brief International Cognitive Assessment in MS [BICAMS] and Brief Repeatable Battery [BRB] and three subtests of the Test Battery of Attentional Performance (TAP). The results of these procedures were considered a gold standard for assessing which patients were cognitively impaired or cognitively unaffected. We also administered the MAT-COBI and compared the results to the gold standard. While the results of an exploratory correlation analysis pointed toward the interpretation that the the MAT-COBI adequately operationalized the basic cognitive domains of attention, memory, and executive, sensitivity was insufficient (32.3 %), while specificity reached 92.3 %. A closer look at the single cognitive domains showed marginal differences across domains (sensitivity ranged from 0–24 %, specificity: 89.5 %-100 %). Based on these results, the MAT-COBI does not appear to be a suitable tool for differentiating between cognitively preserved and cognitively impaired patients with MS. We discuss possible explanations and implications for automated cognitive diagnostics.

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多发性硬化症的计算机神经心理学自动诊断

摘要：认知缺陷在多发性硬化症中很常见，需要诊断和持续监测。然而，频繁的神经心理学评估成本高昂，而且并不总是可行的。对基本认知功能进行计算机化评估有助于在这方面更好地照顾患者。记忆和注意力测试（MAT-COBI）的主要认知量表构成了这样一个工具。在这项可行性研究中，我们对N=44名多发性硬化症患者进行了标准化神经心理评估，该评估包括既定的筛查程序（多发性痴呆症国际认知简要评估[BICAMS]和可重复性简要测验[BRB]）和注意表现测试组（TAP）的三个子测验。这些程序的结果被认为是评估哪些患者认知受损或认知未受影响的黄金标准。我们还使用了MAT-COBI，并将结果与金标准进行了比较。虽然探索性相关性分析的结果表明，MAT-COBI充分操作了注意力、记忆和执行等基本认知领域，但敏感性不足（32.3%），而特异性达到92.3%。仔细观察单个认知领域，发现各领域之间存在边际差异（敏感性在0-24%之间，特异性在89.5%-100%之间）。基于这些结果，MAT-COBI似乎不是区分认知保留和认知受损MS患者的合适工具。我们讨论了自动认知诊断的可能解释和意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zeitschrift Fur Neuropsychologie CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

1.00

自引率

25.00%

发文量

期刊介绍： In der Zeitschrift für Neuropsychologie werden aktuelle Forschungsergebnisse sowie Reviewartikel aus dem Bereich der experimentellen und klinischen Neuropsychologie sowie angrenzender Gebiete (z.B. Biologische Psychologie, Neurologie, Neuropsychiatrie, Neuropsychopharmakologie, Rehabilitationspsychologie) publiziert. Die Beiträge sollen gleichgewichtet sowohl die human- und tierexperimentelle Grundlagenforschung, als auch die klinische Forschung und die klinische Praxis berücksichtigen. Der klinische Schwerpunkt liegt auf der Diagnostik und Rehabilitation von kognitiven und affektiven Störungen, wie z.B. von Aufmerksamkeit, Gedächtnis, Planen und Problemlösen, Sensomotorik, Wahrnehmung, Emotionalität und Sozialverhalten.