Toward a biopsychosocial model of hoarding disorder

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1016/j.jocrd.2022.100775

David F. Tolin

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引用次数: 2

Abstract

The present paper aims to elaborate on the original cognitive-behavioral model of hoarding disorder (HD; Frost & Hartl, 1996) by incorporating the results of recent research on biological and psychological contributors to HD. According to the proposed model, HD is characterized by several vulnerability factors that are thought to increase the likelihood that HD will develop, including genetic predisposition, abnormalities of brain structure, environmental factors such as traumatic life experiences, neuroticism, and impairments of cognitive function. Superimposed on these vulnerability factors is a biphasic abnormality of central and peripheral nervous system activity; at rest, or when doing completing symptom-irrelevant tasks, individuals with HD show blunted activity in brain regions that make up the salience network, including anterior cingulate cortex and insula. This blunted reactivity is further demonstrated through diminished error-related negativity (ERN) and decreased physiological arousal during error trials. However, when individuals with HD make decisions about possessions, they show relative hyperactivation of the salience network (and other brain regions), with accompanying indecisiveness, negative affect, exaggerated ERN, increased physiological arousal, and activation of maladaptive beliefs about, and attachment to, possessions. These factors lead to acquiring and saving behaviors, which are subsequently reinforced through emotion modification.

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囤积障碍的生物心理社会模型

本文旨在阐述囤积障碍(HD;霜,Hartl, 1996)，结合了最近对HD的生物和心理因素的研究结果。根据提出的模型，HD具有几个易感性因素的特征，这些易感性因素被认为会增加HD发展的可能性，包括遗传易感性、大脑结构异常、环境因素，如创伤性生活经历、神经质和认知功能障碍。叠加在这些易感因素上的是中枢和周围神经系统活动的双相异常;在休息或完成与症状无关的任务时，HD患者在组成突出网络的大脑区域表现出迟钝的活动，包括前扣带皮层和脑岛。这种迟钝的反应性通过错误相关负性(ERN)的减少和错误试验期间生理唤醒的减少进一步证明。然而，当HD患者对财产做出决定时，他们的突出网络(和其他大脑区域)表现出相对的过度激活，伴随着犹豫不决、消极情绪、夸张的ERN、增加的生理唤醒，以及对财产的不适应信念和依恋的激活。这些因素导致获取和保存行为，这些行为随后通过情绪调节得到加强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.