Clinically Translatable Phosphonated Silica Microspheres for Selective Internal Radiation Therapy of Hepatocellular Carcinoma

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Small Science Pub Date : 2023-08-22 DOI:10.1002/smsc.202300035

Yi Zhou, Jianxian Ge, Yun Gao, Zhe Yang, M. J. Afshari, Can Chen, Manran Wu, Lei Chen, Shuwang Wu, Guangxin Duan, Jianfeng Zeng, Ming-Yi Gao

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Abstract

Selective internal radiation therapy (SIRT) is used as a locoregional therapy for hepatocellular carcinoma (HCC) to delay the progression of HCC. Thus far, various kinds of radioactive microspheres with different materials and radionuclides have been developed to be utilized in SIRT, but they remain unsatisfactory in some ways. Herein, using a facile method, phosphonated silica microspheres (PSMs) are prepared and further radiolabeled with 177Lu in a rapid and effective manner. The results suggest that the radiolabeling efficiency is higher than 99%, and the specific activity of the product is 10 kBq per microsphere. 177Lu‐PSM exhibits outstanding in vivo radiolabeling stability, excellent antitumor activity, and single‐photon‐emission computed tomography–computed tomography (SPECT/CT) imaging capability. In addition, it is shown that PSM can be produced in large quantities at a relatively low cost. The results indicate that 177Lu‐PSM might hold considerable potential for translation to clinical applications.

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临床可翻译磷酸化二氧化硅微球选择性内照射治疗肝细胞癌

选择性内放射治疗(SIRT)被用作肝细胞癌(HCC)的局部治疗，以延缓HCC的进展。到目前为止，已经开发出各种不同材料和放射性核素的放射性微球用于SIRT，但在某些方面还不尽如人意。本文采用简便的方法制备了磷化二氧化硅微球(psm)，并用177Lu进行了快速有效的放射性标记。结果表明，该产物的放射性标记效率大于99%，比活度为10 kBq /微球。177Lu - PSM具有出色的体内放射性标记稳定性，出色的抗肿瘤活性和单光子发射计算机断层扫描(SPECT/CT)成像能力。此外，还表明PSM可以以相对较低的成本大批量生产。结果表明，177Lu‐PSM可能具有转化为临床应用的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Small Science

CiteScore

14.00

自引率

2.40%

发文量

期刊介绍： Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.