Neutrophil-Lymphocyte Ratio in Patients with Hypertriglyceridemic Pancreatitis Predicts Persistent Organ Failure

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Zhihua Lu, Xiangping Chen, H. Ge, Man Li, Binbin Feng, Donghai Wang, F. Guo
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引用次数: 5

Abstract

Background The neutrophil–lymphocyte ratio (NLR) has been proposed as a surrogate marker of inflammation with prognostic value in various diseases. Our objective was to investigate the predictive value of the NLR as an indicator of persistent organ failure (POF) in patients with hypertriglyceridemic pancreatitis (HTGP). Methods We retrospectively reviewed the data from patients with HTGP between 2016 and 2019. The NLR was obtained at admission. The diagnostic performance of the NLR for POF was evaluated by the area under the receiver operator characteristics curve (AUROC). Multivariate logistic regression determined whether elevated NLR was independently associated with POF. Results Of the 446 patients enrolled, 89 (20.0%) developed POF. Patients with POF showed a significantly higher NLR than those without POF (P < 0.001). A positive trend for the association across increasing NLR quartiles and the incidence of POF was observed (Ptrend < 0.001). The AUROC of NLR to predict POF was 0.673 (95% confidence interval, 0.627-0.716). With a cut-off of NLR > 6.56, the sensitivity and specificity were 73.0% and 55.7%, respectively. Multivariate analysis suggested that high NLR (>6.56) was independently associated with POF (odds ratio, 2.580; 95% confidence interval, 1.439-4.626; P = 0.001). Patients with a high NLR (>6.56) had a worse overall clinical course in HTGP. Conclusion Elevated NLR was significantly associated with an increased risk of developing POF and could be an early independent predictor of POF in patients with HTGP.
高甘油三酯血症胰腺炎患者中性粒细胞-淋巴细胞比率预测持续器官衰竭
中性粒细胞-淋巴细胞比率(NLR)已被提出作为炎症的替代标志物,在各种疾病中具有预后价值。我们的目的是研究NLR作为高甘油三酯血症胰腺炎(HTGP)患者持续性器官衰竭(POF)指标的预测价值。方法回顾性分析2016 - 2019年HTGP患者的资料。在入院时获得NLR。NLR对POF的诊断性能通过接受者操作者特征曲线下面积(AUROC)进行评估。多变量logistic回归确定NLR升高是否与POF独立相关。结果入组的446例患者中,89例(20.0%)发生POF。POF患者NLR明显高于无POF患者(P < 0.001)。随着NLR四分位数的增加,POF的发病率呈上升趋势(p < 0.001)。NLR预测POF的AUROC为0.673(95%可信区间为0.627 ~ 0.716)。截止NLR为6.56,敏感性为73.0%,特异性为55.7%。多因素分析显示,高NLR(>6.56)与POF独立相关(优势比2.580;95%置信区间为1.439-4.626;P = 0.001)。NLR高的患者(bbb6.56)在HTGP的总体临床病程较差。结论NLR升高与发生POF的风险增加显著相关,可能是HTGP患者POF的早期独立预测因子。
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来源期刊
Gastroenterology Research and Practice
Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.40
自引率
0.00%
发文量
91
审稿时长
1 months
期刊介绍: Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.
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