BAR-domain proteins and host membrane remodeling in bacterial invasion

Abstract

Membrane remodeling of targeted host cells is a necessary action for successful bacterial subversion of the host. This includes the formation of membrane ruffles for pathogen entry or the reprogramming of endomembranes during intracellular pathogen trafficking. The importance of BAR domain-containing proteins in such diverse cellular functions highlights their importance in the hijacking of host cells by bacterial pathogens. Given their implication in a variety of cellular functions, such as endocytosis or protein sorting, and being targeted specifically by bacterial effectors, BAR domain-containing proteins likely play a central role in the molecular pathways subverted by invasive bacteria for their niche establishment. Here, we provide an overview of recent work on the contribution of host membrane remodeling factors, with a focus on BAR proteins, and how they are subverted by intracellular bacterial pathogens. The further study of the function of these factors will provide critical insights into the molecular pathways hijacked by bacterial pathogens.