Effect of hyperglycemia treatment on complications rate after pediatric cardiac surgery

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-12 DOI:10.34172/jcvtr.2022.05

B. Naghipour, M. Bagerpour, Kamran Shadvar, S. Golzari, G. Faridaalaee

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引用次数: 0

Abstract

Introduction: The goal of this study was to elucidate harmful complications of intraoperative hyperglycemia following children cardiac surgery and benefits of insulin administration for accurate blood sugar controlling. Methods: this study is a Randomized clinical trial. We conducted this study in the operating room of shahid madani hospital. Fifty patients who were children under 12 years old undergone cardiac surgery using cardiopulmonary bypass (CPB). Intraoperative insulin infusion was administered intravenously targeting blood sugar levels of 110-140 mg/dL. Blood sugar and arterial blood gas (ABG) were measured every 30 min during operation. Results: Inotropes were used less in the study than the placebo group during surgery. The means of hospitalization and extubation time were more in the placebo group than the study group(P =0.03) and (P =0.005), respectively. However, the mean time of hospitalization in the ICU ward did not differ significantly between the two groups. Conclusion: Hyperglycemia has a relation with long time of intubation and hospitalization in ICU. These findings suggest the positive effect of accurate blood sugar control on reducing complication and hospitalization time in children undergoing cardiac surgery.

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高血糖治疗对小儿心脏手术并发症发生率的影响

前言:本研究的目的是阐明儿童心脏手术后术中高血糖的有害并发症以及胰岛素治疗对准确控制血糖的益处。方法:采用随机临床试验。我们在shahid madani医院的手术室进行了这项研究。50例12岁以下儿童接受了体外循环心脏手术。术中静脉注射胰岛素，目标血糖水平为110-140 mg/dL。术中每30 min测一次血糖、动脉血气(ABG)。结果:在手术过程中，肌力药物的使用比安慰剂组少。安慰剂组住院次数和拔管时间分别多于研究组(P =0.03)和研究组(P =0.005)。两组患者在ICU病房的平均住院时间差异无统计学意义。结论:高血糖与ICU插管时间长、住院时间长有关。这些结果提示，准确控制血糖对减少儿童心脏手术并发症和住院时间有积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.