Water-Soluble Carbon Monoxide-Releasing Molecules (CORMs)

IF 7.1 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Huma Khan, Muhammad Faizan, Salamat Ullah Khan Niazi,  Madiha, Niaz Muhammad, Weiqiang Zhang
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引用次数: 1

Abstract

Carbon monoxide-releasing molecules (CORMs) are promising candidates for producing carbon monoxide in the mammalian body for therapeutic purposes. At higher concentrations, CO has a harmful effect on the mammalian organism. However, lower doses at a controlled rate can provide cellular signaling for mandatory pharmacokinetic and pathological activities. To date, exploring the therapeutic implications of CO dose as a prodrug has attracted much attention due to its therapeutic significance. There are two different methods of CO insertion, i.e., indirect and direct exogenous insertion. Indirect exogenous insertion of CO suggests an advantage of reduced toxicity over direct exogenous insertion. For indirect exogenous insertion, researchers are facing the issue of tissue selectivity. To solve this issue, developers have considered the newly produced CORMs. Herein, metal carbonyl complexes (MCCs) are covalently linked with CO molecules to produce different CORMs such as CORM-1, CORM-2, and CORM-3, etc. All these CORMs required exogenous CO insertion to achieve the therapeutic targets at the optimized rate under peculiar conditions or/and triggering. Meanwhile, the metal residue was generated from i-CORMs, which can propagate toxicity. Herein, we explain CO administration, water-soluble CORMs, tissue accumulation, and cytotoxicity of depleted CORMs and the kinetic profile of CO release.

Graphical Abstract

Abstract Image

水溶性一氧化碳释放分子(CORMs)
一氧化碳释放分子(CORMs)是在哺乳动物体内产生一氧化碳用于治疗目的的有希望的候选者。在较高浓度下,一氧化碳对哺乳动物有机体有有害影响。然而,在可控的剂量下,低剂量可以为强制药代动力学和病理活动提供细胞信号。迄今为止,探索CO剂量作为前药的治疗意义因其治疗意义而备受关注。CO的插入方式有间接插入和直接外源插入两种。CO的间接外源性插入比直接外源性插入具有降低毒性的优势。对于间接外源插入,研究人员面临着组织选择性的问题。为了解决这个问题,开发人员考虑了新生成的corm。其中,金属羰基配合物(mcc)与CO分子共价连接,生成不同的corm,如CORM-1、CORM-2和CORM-3等。所有这些CORMs都需要外源性CO插入,才能在特殊条件或/和触发下以最佳速率达到治疗目标。同时,i-CORMs还会产生金属残留物,具有毒性传播作用。在此,我们解释了CO给药、水溶性CORMs、组织积累、耗尽CORMs的细胞毒性以及CO释放的动力学特征。图形抽象
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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry Chemistry-General Chemistry
CiteScore
13.70
自引率
1.20%
发文量
48
期刊介绍: Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.
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