Association of blood pressure variability with target organ damage in older patients with essential hypertension

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2023-06-15 DOI:10.1002/cdt3.73

Zhiquan Jing, Gang Wang, Zeya Li, Shanshan Wu, Xiang Qiu, Rongchong Huang

{"title":"Association of blood pressure variability with target organ damage in older patients with essential hypertension","authors":"Zhiquan Jing, Gang Wang, Zeya Li, Shanshan Wu, Xiang Qiu, Rongchong Huang","doi":"10.1002/cdt3.73","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Although multiple measures of blood pressure variability (BPV) have been proposed, whether they are better than mean blood pressure in predicting target organs is unclear. We aimed to determine the relationship between short term BPV and target organ injury.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This study was a retrospective study, and 635 inpatients in the Department of Cardiology from 2015 to 2020 were selected. We divided participants into four groups on the basis of the quartiles of BPV. One-way analysis of variance was used to compare the differences between the groups, and linear regression was used to analyze the relationship between BPV and target organ damage.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The average age of 635 patients was 74.36 ± 6.50 years old. Among them, 354 of 627 patients had diminished renal function (56.5%), 221of 604 patients had associated left ventricular hypertrophy (36.6%), and 227 of 231 patients had carotid plaque formation (98.3%). The baseline data indicated significant differences in fasting glucose, total cholesterol, low-density lipoprotein, creatinine, glomerular filtration rate, sex, calcium channel blocker use, and the rate of diminished renal function. Multiple linear regression analysis showed that BPV was negatively correlated with renal injury (creatinine: <i>r</i> = 0.306, <i>p</i> < 0.01; estimated glomerular filtration rate: <i>r</i> = 0.058, <i>p</i> < 0.01), and BPV is positively correlated with cardiac injury (<i>r</i> = 0.083, <i>p</i> < 0.01). Elevated BPV was not found to be associated with vascular injury.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Renal function decreases with increasing BPV and left ventricular mass increases with increasing BPV.</p>\n </section>\n </div>","PeriodicalId":32096,"journal":{"name":"Chronic Diseases and Translational Medicine","volume":"9 4","pages":"320-328"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronic Diseases and Translational Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cdt3.73","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Although multiple measures of blood pressure variability (BPV) have been proposed, whether they are better than mean blood pressure in predicting target organs is unclear. We aimed to determine the relationship between short term BPV and target organ injury.

Methods

This study was a retrospective study, and 635 inpatients in the Department of Cardiology from 2015 to 2020 were selected. We divided participants into four groups on the basis of the quartiles of BPV. One-way analysis of variance was used to compare the differences between the groups, and linear regression was used to analyze the relationship between BPV and target organ damage.

Results

The average age of 635 patients was 74.36 ± 6.50 years old. Among them, 354 of 627 patients had diminished renal function (56.5%), 221of 604 patients had associated left ventricular hypertrophy (36.6%), and 227 of 231 patients had carotid plaque formation (98.3%). The baseline data indicated significant differences in fasting glucose, total cholesterol, low-density lipoprotein, creatinine, glomerular filtration rate, sex, calcium channel blocker use, and the rate of diminished renal function. Multiple linear regression analysis showed that BPV was negatively correlated with renal injury (creatinine: r = 0.306, p < 0.01; estimated glomerular filtration rate: r = 0.058, p < 0.01), and BPV is positively correlated with cardiac injury (r = 0.083, p < 0.01). Elevated BPV was not found to be associated with vascular injury.

Conclusion

Renal function decreases with increasing BPV and left ventricular mass increases with increasing BPV.

Abstract Image

查看原文本刊更多论文

老年原发性高血压患者血压变异性与靶器官损伤的关系

背景：尽管已经提出了多种测量血压变异性（BPV）的方法，但它们在预测目标器官方面是否优于平均血压尚不清楚。我们旨在确定短期BPV与靶器官损伤之间的关系。方法：本研究为回顾性研究，选取2015年至2020年心内科住院患者635例。我们根据BPV的四分位数将参与者分为四组。采用单向方差分析比较各组之间的差异，并采用线性回归分析BPV与靶器官损伤之间的关系。结果：635例患者的平均年龄为74.36岁 ± 6.50岁。其中，627例患者中有354例肾功能下降（56.5%），604例患者中221例伴有左心室肥大（36.6%），231例患者中227例颈动脉斑块形成（98.3%）。基线数据显示，空腹血糖、总胆固醇、低密度脂蛋白、肌酸酐、肾小球滤过率、性别、钙通道阻滞剂的使用，以及肾功能下降的比率。多元线性回归分析显示，BPV与肾损伤呈负相关（肌酐： = 0.306，p r = 0.058，p r = 0.083，p 结论：肾功能随着血压的升高而下降，左心室质量随着血压的增加而增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.