Suitable Interpretation of Skin Prick Test and Biomedical Guidance Leads to a Better Clinical State in Atopic Individuals with High Indoor Permanence: Possible Therapeutic Implications

B. Y. Nakamatsu, A. Fernandes, Débora da Silva, L. S. Santos, Thamires Rodrigues de Sousa, J. R. Victor
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Abstract

Indoor conditions contribute to allergen sensitization and multiple allergens reactivity, mainly for inhaled allergens. This study analyzes if Skin Prick Test (SPT) combined with efficient individual biomedical guidance about allergy development’s social, biological, and environmental aspects can yield a better clinical state with therapeutic implications for atopic individuals with high indoor permanence. We recruited atopic and non-atopic volunteers (clinically and in vitro diagnosed) with indoor permanence above 15 h per day and without previous SPT evaluation. The SPT and serum anti-allergen IgE analyses were performed individually in person, demonstrated, and discussed by the practitioners. Six months after, SPT and specific IgE titers determination were repeated, and a questionnaire to evaluate the effectiveness of the practitioner’s orientation was performed. After six months, 14% of atopic volunteers reported changes in their social habits, 30% said that they avoid the development of allergies clinical symptoms, and 68% reported a substantial improvement in their health after being informed mentored about their allergen reactivity. The control non-atopic group, as expected, reported no changes in social habits, the maintenance of total avoidance of allergic symptoms, and almost no improvement of their health. Reduced SPT and serum allergen-specific IgE titers were detected in the atopic individuals corroborating with questionnaire results. Our results indicated that SPT, followed by an individual and efficient discussion about the main biomedical aspects of allergy development, could exert a pronounced therapeutic role in allergy development by high indoor permanence individuals.
皮肤点刺试验和生物医学指导的适当解释导致高室内持久性的特应性个体更好的临床状态:可能的治疗意义
室内环境会导致过敏原致敏和多种过敏原反应,主要是吸入性过敏原。本研究分析了皮肤点刺试验(SPT)结合对变态反应发展的社会、生物和环境方面的有效的个体生物医学指导是否能对具有高室内持久性的特应性个体产生更好的临床状态和治疗意义。我们招募了特应性和非特应性志愿者(临床和体外诊断),他们每天在室内停留15小时以上,没有以前的SPT评估。SPT和血清抗过敏原IgE分析是单独进行的,由医生演示和讨论。6个月后,再次进行SPT和特异性IgE滴度测定,并进行问卷调查以评估医生指导的有效性。六个月后,14%的过敏性反应志愿者报告说他们的社交习惯发生了变化,30%的人说他们避免了过敏临床症状的发展,68%的人报告说,在被告知他们的过敏原反应后,他们的健康状况有了实质性的改善。如预期的那样,非特应性反应的对照组在社交习惯上没有改变,保持完全避免过敏症状,而且他们的健康状况几乎没有改善。在特应性个体中检测到SPT和血清过敏原特异性IgE滴度降低,与问卷调查结果相吻合。我们的研究结果表明,SPT,然后是对过敏发展的主要生物医学方面的个体和有效的讨论,可以在高室内持久性个体的过敏发展中发挥显著的治疗作用。
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