Coronavirus disease 2019-associated mucormycosis of the head-and-neck area: A new rise of dreaded black fungus in the current pandemic

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
S. Swain, P. Jena
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Abstract

Coronavirus disease 2019 (COVID-19) pandemic is currently evolving and associated with more complications with invasive fungal infection like mucormycosis. Classically, uncontrolled diabetes mellitus (DM) and other immunosuppressive conditions like corticosteroid therapy are known risk factors for causing mucormycosis in COVID-19 patients. Mucormycosis is an invasive fungal infection which rapidly spread to the orbit and brain from the nasal cavity and paranasal sinuses. Mucormycosis in COVID-19 is a fatal to the patient. There is possibility of COVID-19 as a trigger factor for diabetic ketoacidosis which predisposes to invasive fungal infections such as mucormycosis. Patients with poorly controlled DM and immunocompromised conditions increase the risk for development of COVID-19 infections in COVID-19 patients. During the current COVID-19 pandemic, a myriad of clinical manifestations and complications are emerged. Rhino-orbital-cerebral mucormycosis is a fatal clinical entity associated with COVID-19 infections resulting in higher morbidity and mortality. The treatment includes both medical and surgical interventions. It requires early and adequate treatment with amphotericin B and surgical debridement and control of risk factors. A multidisciplinary approach by otorhinolaryngologists, ophthalmologists, neurologists, and dentists is successful for treatment of COVID-19 patients with mucormycosis in the head-and-neck region. Identification of the risk factors and early preventive measures will minimize the incidence of life-threatening mucormycosis in the head-and-neck area of COVID-19 patients.
2019冠状病毒病相关的头颈部毛霉菌病:当前疫情中可怕的黑真菌的新崛起
2019冠状病毒病(新冠肺炎)大流行目前正在演变,并与毛霉菌病等侵袭性真菌感染的更多并发症有关。传统上,未控制的糖尿病(DM)和皮质类固醇治疗等其他免疫抑制疾病是导致新冠肺炎患者毛霉菌病的已知危险因素。毛霉菌病是一种侵袭性真菌感染,可从鼻腔和鼻窦迅速传播到眼眶和大脑。新冠肺炎的毛霉菌病对患者来说是致命的。新冠肺炎可能是糖尿病酮酸中毒的触发因素,酮酸中毒易患侵袭性真菌感染,如毛霉菌病。DM控制不佳和免疫功能低下的患者增加了新冠肺炎患者发展为COVID-19]感染的风险。在当前新冠肺炎大流行期间,出现了无数的临床表现和并发症。鼻-眶-脑毛霉菌病是一种与新冠肺炎感染相关的致命临床实体,导致更高的发病率和死亡率。治疗包括医疗和外科干预。它需要早期和充分的两性霉素B治疗和外科清创术,并控制风险因素。耳鼻喉科医生、眼科医生、神经科医生和牙医的多学科方法成功治疗了头颈部新冠肺炎毛霉菌病患者。风险因素的识别和早期预防措施将最大限度地降低新冠肺炎患者头颈部危及生命的毛霉菌病的发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the Scientific Society
Journal of the Scientific Society MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
19
审稿时长
36 weeks
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