Immunofluorescent Identification of GABAergic Structures in the Somatic Muscle of the Earthworm Lumbricus terrestris

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2023-08-14 DOI:10.1134/S1990747823040074

L. F. Nurullin, N. D. Almazov, E. M. Volkov

引用次数: 0

Abstract—

Using the immunofluorescence confocal microscopy, we detected the following GABAergic structures in the somatic muscle of the body wall of the earthworm: neurotransmitter gamma-aminobutyric acid (GABA); the enzyme responsible for synthesis of GABA, glutamate decarboxylase; type 1, 2, and 3 membrane transporters of GABA providing its reuptake; pre- and postsynaptic type A (ionotropic) and type B (metabotropic) GABA receptors. These structures are localized in the areas of cholinergic neuromuscular synapses. We assume that GABA can participate in modulation of motor activity of the earthworm somatic muscles both at pre- and postsynaptic levels of cholinergic neuromuscular synapses.

Abstract Image

查看原文本刊更多论文

地蚓体肌gaba能结构的免疫荧光鉴定

摘要/ abstract摘要:利用免疫荧光共聚焦显微镜观察蚯蚓体壁体肌中GABA能结构:神经递质γ -氨基丁酸(GABA);负责合成GABA的酶，谷氨酸脱羧酶;提供GABA再摄取的1、2和3型膜转运体;突触前和突触后A型(嗜离子性)和B型(代谢性)GABA受体。这些结构位于胆碱能神经肌肉突触区域。我们假设GABA可以参与调节蚯蚓体肌在突触前和突触后水平的胆碱能神经肌肉突触的运动活动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.