Role of microRNA-182 in skeletal diseases: new therapeutic approaches to prevent bone loss

Abstract

The onset of bone erosion is associated to several diseases, including metabolic processes as hyperparathyroidism, malignancies, chronic inflammation such as rheumatoid arthritis and osteoporosis (1). This condition leads to mobility loss, functional impairment, pains and fractures with a dramatically reduction of patients’ life quality. The resulting bone loss reflects, basically, an imbalance of osteoclasts and osteoblasts activity where bone formation is replaced by its resorption (2).