Electrospun polyurethane-based vascular grafts: physicochemical properties and functioning in vivo

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2019-11-06 DOI:10.1088/1748-605X/ab550c

A. Gostev, V. Chernonosova, I. Murashov, D. Sergeevichev, Alexander A Korobeinikov, A. Karaskov, A. Karpenko, P. Laktionov

引用次数: 9

Abstract

General physicochemical properties of the vascular grafts (VGs) produced from the solutions of Tecoflex (Tec) with gelatin (GL) and bivalirudin (BV) by electrospinning are studied. The electrospun VGs of Tec-GL-BV and expanded polytetrafluoroethylene (e-PTFE) implanted in the abdominal aorta of 36 Wistar rats have been observed over different time intervals up to 24 weeks. A comparison shows that 94.5% of the Tec-GL-BV VGs and only 66.6% of e-PTFE VGs (р = 0.0438) are free of occlusions after a 6 month implantation. At the intermediate observation points, Tec-GL-BV VGs demonstrate severe neovascularization of the VG neoadventitial layer as compared with e-PTFE grafts. A histological examination demonstrates a small thickness of the neointima layer and a low level of calcification in Tec-GL-BV VGs as compared with the control grafts. Thus, polyurethane-based protein-enriched VGs have certain advantages over e-PTFE VGs, suggesting their utility in clinical studies.

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静电纺聚氨酯基血管移植物:物理化学性质和体内功能

用静电纺丝法研究了Tecoflex (Tec)与明胶(GL)和比伐鲁定(BV)溶液制备的血管移植物的一般理化性质。在24周内观察了36只Wistar大鼠腹主动脉内植入Tec-GL-BV和膨胀聚四氟乙烯(e-PTFE)的电纺丝VGs。结果表明，在植入6个月后，94.5%的Tec-GL-BV VGs和66.6%的e-PTFE VGs (r = 0.0438)没有出现咬合。在中间观察点，与e-PTFE移植物相比，Tec-GL-BV移植物表现出严重的VG新外膜新生血管。组织学检查显示，与对照移植物相比，Tec-GL-BV移植物的新生内膜层厚度小，钙化程度低。因此，基于聚氨酯的富含蛋白质的VGs比e-PTFE VGs具有一定的优势，这表明它们在临床研究中的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters