Analysis of the vascular risk factors for the elderly with mild cognitive impairment in community

中华行为医学与脑科学杂志 Pub Date : 2019-10-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.10.001

Pei Sun, C. Luo, Qingqing Geng, Qian Zhang, Shuan-Chih Chen, Wendi Wang, Xiang Wang, Yifeng Du, C. Qu

{"title":"Analysis of the vascular risk factors for the elderly with mild cognitive impairment in community","authors":"Pei Sun, C. Luo, Qingqing Geng, Qian Zhang, Shuan-Chih Chen, Wendi Wang, Xiang Wang, Yifeng Du, C. Qu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.10.001","DOIUrl":null,"url":null,"abstract":"Objective \nTo explore the effects of vascular risk factors on cognitive function among the elderly in community. \n \n \nMethods \nA cross-sectional study was conducted in 1 269 elderly people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, cognitive function was assessed by mini-mental state examination(MMSE), and blood samples were collected for laboratory examination.Logistic regression analysis was used to analyze the vascular risk factors affecting cognitive function. \n \n \nResults \nAge ((73.1±6.6), (71.3±4.9), t=4.603, P<0.05), education level (χ2=12.727, P<0.05), hypertension (χ2=9.106, P<0.05) and LDL-C (χ2=5.157, P<0.05) were significantly different in the elderly with or without mild cognitive impairment(MCI). After controlling age, gender and education, the logistic regression analysis showed that hypertension(β=0.378, P=0.006, OR(95%CI)=1.44(1.10-1.91)), systolic blood pressure ≥140 mmHg(β=0.350, P=0.011, OR(95%CI)=1.42(1.08-1.86), 1 mmHg=0.133 kPa), and high LDL-C(β=0.355, P=0.014, OR(95%CI)=1.43(1.08-1.89)) were the risk factors of MCI in the elderly in the community.Hypertension alone or high LDL-C (β=0.365, P=0.029, OR(95%CI)=1.44(1.04-2.00)) alone was risk factor for mild cognitive impairment in the elderly in the community.The risk of mild cognitive impairment in the elderly with hypertension and high LDL-C was 2.00 times higher than that in the healthy elderly (β=0.696, P<0.05, OR(95%CI)=2.00(1.36-2.97)). \n \n \nConclusion \nMild cognitive impairment in the elderly is closely related to hypertension and elevated LDL-C levels.Multiple vascular risk factors can further increase the risk of cognitive impairment. \n \n \nKey words: \nCognitive impairment; Vascular risk factors; Hypertension; Elderly","PeriodicalId":9940,"journal":{"name":"中华行为医学与脑科学杂志","volume":"28 1","pages":"865-869"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华行为医学与脑科学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.10.001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To explore the effects of vascular risk factors on cognitive function among the elderly in community. Methods A cross-sectional study was conducted in 1 269 elderly people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, cognitive function was assessed by mini-mental state examination(MMSE), and blood samples were collected for laboratory examination.Logistic regression analysis was used to analyze the vascular risk factors affecting cognitive function. Results Age ((73.1±6.6), (71.3±4.9), t=4.603, P<0.05), education level (χ2=12.727, P<0.05), hypertension (χ2=9.106, P<0.05) and LDL-C (χ2=5.157, P<0.05) were significantly different in the elderly with or without mild cognitive impairment(MCI). After controlling age, gender and education, the logistic regression analysis showed that hypertension(β=0.378, P=0.006, OR(95%CI)=1.44(1.10-1.91)), systolic blood pressure ≥140 mmHg(β=0.350, P=0.011, OR(95%CI)=1.42(1.08-1.86), 1 mmHg=0.133 kPa), and high LDL-C(β=0.355, P=0.014, OR(95%CI)=1.43(1.08-1.89)) were the risk factors of MCI in the elderly in the community.Hypertension alone or high LDL-C (β=0.365, P=0.029, OR(95%CI)=1.44(1.04-2.00)) alone was risk factor for mild cognitive impairment in the elderly in the community.The risk of mild cognitive impairment in the elderly with hypertension and high LDL-C was 2.00 times higher than that in the healthy elderly (β=0.696, P<0.05, OR(95%CI)=2.00(1.36-2.97)). Conclusion Mild cognitive impairment in the elderly is closely related to hypertension and elevated LDL-C levels.Multiple vascular risk factors can further increase the risk of cognitive impairment. Key words: Cognitive impairment; Vascular risk factors; Hypertension; Elderly

查看原文本刊更多论文

社区轻度认知障碍老年人血管危险因素分析

目的探讨社区老年人血管危险因素对认知功能的影响。方法从三个社区随机抽取1269名65岁及以上的老年人进行横断面调查。通过面对面访谈，通过简易精神状态检查（MMSE）评估认知功能，并采集血样进行实验室检查。采用Logistic回归分析法分析影响认知功能的血管危险因素。结果年龄（73.1±6.6），（71.3±4.9），t=4.603，P<0.05），文化程度（χ2=12.727，P<0.05）、高血压（χ2=9.106，P<0.05）和低密度脂蛋白胆固醇（χ2=5.157，P<0.05）在轻度认知障碍和非轻度认知障碍老年人中有显著差异。在控制年龄、性别和教育程度后，逻辑回归分析显示，高血压（β=0.378，P=0.006，OR（95%CI）=1.44（1.10-1.91））、收缩压≥140 mmHg（β=0.350，P=0.011，OR（95%CI）=1.42（1.08-1.86），1 mmHg=0.133kPa）和高LDL-C（β=0.355，P=0.014，OR（95%CI）=1.43（1.08-11.89））是社区老年人MCI的危险因素。单独高血压或单独高LDL-C（β=0.365，P=0.029，or（95%CI）=1.44（1.04-2.00））是社区老年人轻度认知障碍的危险因素。患有高血压和高LDL-C的老年人发生轻度认知障碍的风险是健康老年人的2.00倍（β=0.696，P<0.05，OR（95%CI）=2.00（1.36-2.97））。结论老年人轻度认知障碍与高血压和LDL-C水平升高密切相关。多种血管风险因素会进一步增加认知障碍的风险。关键词：认知障碍；血管危险因素；高血压；老年人

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华行为医学与脑科学杂志

自引率

0.00%

发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.