On the mutation model used in the fingerprinting DNA

IF 1.2 Q3 Computer Science

Bio-Algorithms and Med-Systems Pub Date : 2020-12-04 DOI:10.1515/bams-2020-0057

A. Krajka, Ireneusz Panasiuk, Adam Misiura, Grzegorz M. Wójcik

引用次数: 0

Abstract

Abstract Objectives The most common technique of determining biological paternity or another relationship among people are the investigations of DNA polymorphism called Fingerprinting DNA. The key concept of these investigations is the statistical analysis, which leads to obtain the likelihood ratio (LR), sometimes called the paternity index. Methods Among the different assumptions stated in these computations is a mutation model (this model is used for all the computations). Results and conclusions Although its influence on LR is usually negligible, there are some situations (when the mother–child mutation arises) when it is crucial.

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DNA指纹识别中使用的突变模型

摘要目的确定人与人之间的生物学亲子关系或其他关系的最常见技术是DNA多态性的研究，即指纹DNA。这些调查的关键概念是统计分析，它可以获得似然比（LR），有时称为亲子指数。方法在这些计算中提出的不同假设中有一个突变模型（该模型用于所有计算）。结果和结论尽管它对LR的影响通常可以忽略不计，但在某些情况下（当母婴突变出现时），它是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bio-Algorithms and Med-Systems MATHEMATICAL & COMPUTATIONAL BIOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.