Polyvinyl alcohol/citric acid/β-cyclodextrin/CuONP composite nanofibers as an effective and green absorbent for the simultaneous extraction of three antidepressant drugs in biological fluids prior to GC-FID analysis

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2023-05-13 DOI:10.1007/s00604-023-05800-4

Farbod Kharazmi, Fatemeh Sadat Hosseini, Homeira Ebrahimzadeh

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引用次数: 3

Abstract

Composite nanofibers, namely, polyvinyl alcohol (PVA), citric acid (CA), β-cyclodextrin (β–CD), and copper oxide nanoparticles (PVA/CA/β-cyclodextrin/CuO NPs), were developed as a novel, green, and efficient adsorbent in the pipette tip-micro-solid-phase extraction method (PT-µSPE), for the simultaneous extraction of three antidepressants drugs namely imipramine (IMP), citalopram (CIT), and clozapine (CLZ) in biological fluids before quantification by gas chromatography (GC-FID). Based on the obtained results from field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD), the successful synthesis of composite nanofibers was approved. Due to the presence of β-cyclodextrins and CuO NPs rich of functional groups on their surface, the nanofibers have high extraction efficiency. Under the optimal conditions, the linear range for imipramine, citalopram, and clozapine was 0.1 to 1000.0 ng mL⁻¹ with a determination coefficient ≥ 0.99. The limits of detection (LODs) were in the range 0.03 to 0.15 ng mL⁻¹. The relative standard deviation was 4.8 to 8.7% (within-day, n = 4) and 5.1 to 9.2% (between-day, n = 3) for 3 consecutive days. In addition, excellent clean-up was achieved which is a great advantage over other sample preparation methods. Finally, the ability of the developed method to extract the target analytes from the biological samples was evaluated.

Graphical Abstract

Abstract Image

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聚乙烯醇/柠檬酸/β-环糊精/CuONP 复合纳米纤维作为一种有效的绿色吸收剂，用于在 GC-FID 分析前同时提取生物液体中的三种抗抑郁药物

摘要开发了聚乙烯醇（PVA）、柠檬酸（CA）、β-环糊精（β-CD）和氧化铜纳米颗粒（PVA/CA/β-环糊精/CuO NPs）复合纳米纤维，作为一种新型、绿色、高效的吸附剂，在移液管吸头-微固相萃取法（PT-µSPE）中用于同时萃取三种抗抑郁药物，即丙咪嗪（IMP）、丙咪嗪（CMP）和丙咪嗪（CMP）、吸头-微固相萃取法（PT-µSPE）同时萃取生物液体中的三种抗抑郁药物，即丙咪嗪（IMP）、西酞普兰（CIT）和氯氮平（CLZ），然后用气相色谱法（GC-FID）进行定量。根据场发射扫描电子显微镜（FE-SEM）、能量色散 X 射线光谱（EDX）、傅立叶变换红外光谱（FT-IR）和 X 射线衍射（XRD）的结果，成功合成了复合纳米纤维。由于β-环糊精和表面富含官能团的 CuO NPs 的存在，纳米纤维具有很高的萃取效率。在最佳条件下，丙咪嗪、西酞普兰和氯氮平的线性范围为0.1～1000.0 ng mL-1，测定系数≥0.99。检出限为 0.03 至 0.15 纳克/毫升。连续 3 天的相对标准偏差为 4.8%至 8.7%（日内，n = 4）和 5.1%至 9.2%（日间，n = 3）。此外，与其他样品制备方法相比，该方法的净化效果极佳。最后，评估了所开发方法从生物样品中提取目标分析物的能力。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.