Comparison of azithromycin and a combination of trypsin, chymotrypsin and papain proteolytic enzymes for the treatment of bovine cutaneous papillomatosis

IF 0.5 4区农林科学 Q4 VETERINARY SCIENCES

Veterinaria Mexico Pub Date : 2022-06-16 DOI:10.22201/fmvz.24486760e.2022.888

M. Deveci, M. Altuğ, H. Alakuş, Ş. Ozsoy

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引用次数: 0

Abstract

Although various methods have been used in the treatment of bovine cutaneous papillomatosis (BCP), no definite treatment has yet been established. There are no studies regarding the efficacy of azithromycin (AZ) and of any combination of trypsin, chymotrypsin, and papain proteolytic enzymes (PEC) in the treatment of BCP. The objective of this study was to investigate the efficacy of AZ and PEC in the treatment of BCP. A total of 24 female Holstein cattle of 6-17 months of age with spontaneous BCP were used for this study. In addition to the clinical findings, the diagnosis was confirmed with histopathological examinations. The animals were divided at random into three groups (n = 8). The AZ group received 10 mg/kg/day PO for 10 days. In the PEC group, an injectable suspension of proteolytic enzymes was applied IM at 0.4 mL/10 kg dose, 3 times with 8-10 days interval and the spray was used topically once a day for 10 days. The control group (CO) was not treated. The mean in papilloma warts decreased 92.4 % in the AZ group, 83.38 % in the PEC group, and 59.48 % in the CO. There were statistically significant differences in warts presence decreases between the three groups (P < 0.05). Both AZ and PEC were considered successful for the BCP treatment. However, AZ was found more effective than PEC.

查看原文本刊更多论文

阿奇霉素与胰蛋白酶、糜蛋白酶和木瓜蛋白酶联合蛋白水解酶治疗牛皮肤乳头状瘤病的比较

尽管已经使用了各种方法来治疗牛皮肤乳头状瘤病（BCP），但还没有确定的治疗方法。目前还没有关于阿奇霉素（AZ）和胰蛋白酶、糜蛋白酶和木瓜蛋白酶（PEC）的任何组合治疗BCP的疗效的研究。本研究的目的是研究AZ和PEC治疗BCP的疗效。本研究共使用了24头6-17个月大的雌性荷斯坦牛，它们患有自发性BCP。除了临床表现外，组织病理学检查也证实了诊断。将动物随机分为三组（n=8）。AZ组接受10 mg/kg/天的PO，持续10天。在PEC组中，蛋白水解酶的可注射悬浮液以0.4mL/10kg的剂量IM施用，3次，间隔8-10天，喷雾每天局部使用一次，持续10天。对照组（CO）未接受治疗。AZ组、PEC组和CO组的乳头状瘤疣平均数分别下降了92.4%、83.38%和59.48%。三组之间的疣存在率下降有统计学意义（P<0.05）。AZ和PEC均被认为是BCP治疗的成功。然而，AZ比PEC更有效。

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来源期刊

Veterinaria Mexico Veterinary-General Veterinary

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Veterinaria México OA (ISSN 2448-6760) is an online scientific journal edited by Universidad Nacional Autónoma de México (UNAM). The journal is Open Access and follows UNAM''s initiative, to transmit knowledge free of charge to the readership and authors, with no Article Processing Charges. This journal publishes advances in Veterinary Sciences and Animal Production, and to reach more lectures across the world the journal was updated since 2014 from its predecessor printed in paper Veterinaria México (ISSN 0301-5092) and its digital version (ISSN 2007-5472).