Environmental friendly carrier material for nifedipine as hypertension drug

IF 3.1 Q2 ENVIRONMENTAL SCIENCES
E. Budianto, S. Astuti
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引用次数: 0

Abstract

Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be environmentally friendly polymers, because they can be degraded naturally in nature both in the biotic, and abiotic environment, or microorganism. In this study, polylactic acid, Polycaprolactone, and nifedipine were dissolved in dichloromethane solvent; then, an emulsifier was added for the emulsification stage. After passing through the dispersion stage for the process of compaction of the microcapsules by solvent evaporation, the microcapsules were filtered. Microcapsules were characterized using particle size analysis, X-ray diffractometry, and scanning electron microscopy, respectively. The drug release percentage was determined by dissolving microcapsules for 55 hours using a buffer at the potential of hydrogen 1.2 and pH 7.4 as dissolution media. In this study, all variations in the composition of polyblend resulted in a percent efficiency of encapsulation ranging from 78.82%-89.84%, and percent release ranging from 6.80%-39.07%. The composition of 100% polylactic acid produces the highest percent encapsulation efficiency of 89.84% but produces the lowest percentage of drug release at 6.80%. The best composition obtained was polylactic acid: polycaprolactone 1:9 (weight per weight), with a percent release of 39.07% and percent encapsulation of 78.82%. Microcapsule solids produced are approximately 96%. Particle Size of microcapsule ranges at 0.5 μM.
硝苯地平作为高血压药物的环保载体材料
硝苯地平是一种高血压药物,由于其口服生物利用度低,必须每天服用三次。开发可控药物递送系统的一种方法是通过使用水包油溶剂的蒸发法,使用环境友好的聚乳酸和聚己内酯聚合物制备硝苯地平微胶囊。聚乳酸和聚己内酯可以说是环境友好的聚合物,因为它们可以在生物、非生物环境或微生物中自然降解。在本研究中,将聚乳酸、聚己内酯和硝苯地平溶解在二氯甲烷溶剂中;然后,添加乳化剂用于乳化阶段。在通过用于通过溶剂蒸发压实微胶囊的过程的分散阶段之后,过滤微胶囊。分别使用粒度分析、X射线衍射仪和扫描电子显微镜对微胶囊进行了表征。药物释放百分比是通过使用电势为氢1.2和pH 7.4的缓冲液作为溶解介质将微胶囊溶解55小时来测定的。在本研究中,共混物组成的所有变化导致包封率在78.82%-89.84%之间,100%聚乳酸的包封率最高,为89.84%,但药物释放率最低,为6.80%。得到的最佳组合物是聚乳酸:聚己内酯1:9(重量/重量),释放率为39.07%,包封率为78.82%。产生的微胶囊固体约为96%。微胶囊的粒径范围为0.5μM。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.90
自引率
2.90%
发文量
11
审稿时长
8 weeks
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