Bioactive Secondary Metabolites Extracted from Some Species of Candida Isolated from Women Infected with Vulvovaginal Candidiasis

Abstract

Candida spp. are well known for their impact on our life as opportunistic pathogens and can produce secondary metabolites, which are an interesting source of high-value chemicals and are often diffi cult to synthesize chemically. Some of these metabolites are already being used as active antimicrobials or pharmaceuticals. GC-MS analysis of chemical compounds was conducted in ethyl acetate of fi ve Candida species (C. parapsilosis, C. albicans, C. krusei, C. glabrata and C. kefyr). The results showed that about 249 chemical compounds were detected from all tested Candida species. Fifteen bioactive compounds identifi ed in secondary metabolites of all tested species. Benzene, pentamethyl, n-hexadecanoic acid, 1-docosene and bis(2-ethylhexyl) produced by C. parapsilosis, C. albicans, C. krusei and C. glabrata. All tested Candida except C. krusei produced 3buten- 1-ol and ethyl acetoacetate ethylene acetal. Benzen, 2-ethenyl-1,3-dimethyl- a compound found in four tested Candida except C. albicans, benezene, (1-ethyl-1-propenyl)- produced by all species except C. glabrata, acetic acid, cyclohexyl ester produced by C. parapsilosis, C. albicans and C. glabrata.